| Gene Symbol |
SLC29A4
|
| Entrez Gene |
222962
|
| Alt Symbol |
ENT4, PMAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 29 (equilibrative nucleoside transporter), member 4
|
| Other Description |
equilibrative nucleoside transporter 4|plasma membrane monoamine transporter|solute carrier family 29 (nucleoside transporters), member 4|solute carrier family 29 member 4
|
| Swissprots |
Q8NBM2 Q6PJ08 Q7RTT9 Q86WY8 Q8NAR3
|
| Accessions |
DAA00308 EAW87329 EAW87330 Q7RTT9 AK075422 BAC11612 AK092242 BAC03836 AK296278 BAG58987 AL515106 AY485959 AAS65965 BC025325 AAH25325 BC047592 AAH47592 BM069878 BU740709 H07897 XM_005249658 XP_005249715 XM_006715667 XP_006715730 XM_006715668 XP_006715731 XM_011515200 XP_011513502 XM_011515201 XP_011513503 NM_001040661 NP_001035751 NM_001300847 NP_001287776 NM_153247 NP_694979
|
| Function |
Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to chang
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718}.
|
| Tissue Specificity |
Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes putamen and in the spinal cord. Lower expression in liver, pancreas, and liver. Expressed in endometrial tissue, exclusively in the stroma. Expression is high in the proliferative phase, decreases during the secretory phase, and is no longer detectable in the menstrual phase. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17393420}.
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