| Gene Symbol |
Npr1
|
| Entrez Gene |
24603
|
| Alt Symbol |
Anpra, Gca, NPR-A, Npra
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
natriuretic peptide receptor 1
|
| Other Description |
ANP-A|ANPR-A|GC-A|atrial natriuretic peptide A-type receptor|atrial natriuretic peptide receptor 1|atrial natriuretic peptide receptor A|atrial natriuretic peptide receptor type A|guanylate cyclase A|natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
|
| Swissprots |
P18910 A1A5N8
|
| Accessions |
AAA41200 EDM00568 EDM00569 P18910 BC081831 BC128742 AAI28743 M74535 AAA41202 X14773 CAA32881 XM_006232591 XP_006232653 NM_012613 NP_036745
|
| Function |
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Purine metabolism
|