| Gene Symbol |
Eid2
|
| Entrez Gene |
386655
|
| Alt Symbol |
Cri2, EID-2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
EP300 interacting inhibitor of differentiation 2
|
| Other Description |
CREBBP/EP300 inhibitor 2|CREBBP/EP300 inhibitory protein 2|E1A like inhibitor of differentiation 2|EID-1-like inhibitor of differentiation 2|EP300-interacting inhibitor of differentiation 2|eid2
|
| Swissprots |
Q6X7S9
|
| Accessions |
Q6X7S9 AY251273 AAP12560 BC094513 AAH94513 NM_198425 NP_940817
|
| Function |
Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). {ECO:0000250|UniProtKB:Q8N6I1}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q8N6I1}.
|
| Tissue Specificity |
Expressed in heart, brain, kidney and pancreas. Not detected in placenta. {ECO:0000269|PubMed:14585496}.
|