Gene Symbol | SDR16C5 |
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Entrez Gene | 195814 |
Alt Symbol | RDH#2, RDH-E2, RDHE2 |
Species | Human |
Gene Type | protein-coding |
Description | short chain dehydrogenase/reductase family 16C, member 5 |
Other Description | EPHD-2|epidermal retinal dehydrogenase 2|epidermal retinol dehydrogenase 2|retSDR2|retinal short chain dehydrogenase reductase|retinal short-chain dehydrogenase reductase 2|short-chain dehydrogenase/reductase family 16C member 5 |
Swissprots | B4DGK2 Q96LX1 Q330K3 Q8N3Y7 Q8TDV9 |
Accessions | EAW86780 EAW86781 EAW86782 Q8N3Y7 AB083038 BAB91014 AK057667 BAB71545 AK095159 BAG52996 AK294634 BAG57813 AY444559 AAS68535 BC037219 AAH37219 BC064525 AAH64525 XM_005251180 XP_005251237 XM_011517478 XP_011515780 XM_011517479 XP_011515781 NM_138969 NP_620419 |
Function | Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. {ECO:0000269|PubMed:18926804}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung. {ECO:0000269|PubMed:12372410}. |
Top Pathways | Retinol metabolism |
Human RDHE2 protein fragment - ab140552 from Abcam
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RDHE2 / SDR16C5 Antibody Blocking Peptide - LS-E3692 from LifeSpan Bioscience
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RDHE2 / SDR16C5 Antibody Blocking Peptide - LS-E18963 from LifeSpan Bioscience
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SDR16C5 Recombinant Protein - H00195814-P01 from Novus Biologicals
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Recombinant Human SDR16C5 Protein - NBP2-23469 from Novus Biologicals
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SDR16C5-Antibody-Center-Blocking-Peptide - BP14895c from Abgent, a WuXi AppTec company
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Human SDR16C5 protein - orb169266 from Biorbyt
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RDHE2 Blocking Peptide - 33R-1208 from Fitzgerald
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SDR16C5 protein (His tag) - 80R-2697 from Fitzgerald
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RDHE2 / SDR16C5 (32-269, His-tag) - AR50817PU-N from Acris Antibodies
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RDHE2 / SDR16C5 (32-269, His-tag) - AR50817PU-S from Acris Antibodies
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RDHE2 / SDR16C5 - H00195814-P01-10 from Acris Antibodies
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RDHE2 / SDR16C5 - H00195814-P01-25 from Acris Antibodies
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SDR16C5, 32-269aa, Human, His tag, E.coli - 01-P1993 from ARP American Research Products
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SDR16C5 fusion protein - ag5261 from Proteintech Group
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SDR16C5 Human - PRPS-1392 from NeoScientific
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Recombinant Human SDR16C5, His-tagged - SDR16C5-7549H from Creative Biomart
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SDR16C5, 32-269aa, Human, His tag, E.coli - ATGP1993 from ATGen
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Short Chain Dehydrogenase/Reductase Family 16C, Member 5 Protein (Recombinant) - abx261030 from Abbexa
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RDHE2 / SDR16C5 - TP306759 from Acris Antibodies
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SDR16C5 Recombinant Protein Antigen - NBP1-87150PEP from Novus Biologicals
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SDR16C5 Peptide, Human - M34GP13925H from Creative Peptides
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SDR16C5 - PAT-81992-1 from Nordic BioSite
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SDR16C5 - PAT-81992-2 from Nordic BioSite
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Short Chain Dehydrogenase/Reductase Family 16C, Member 5, Human Recombinant - 228-21491-1 from RayBiotech
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