| Gene Symbol |
ANGPT4
|
| Entrez Gene |
51378
|
| Alt Symbol |
AGP4, ANG-3, ANG4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
angiopoietin 4
|
| Other Description |
ANG-4|angiopoietin-3|angiopoietin-4|dJ824F16.2 (angiopoietin 4)
|
| Swissprots |
Q9H4Z4 Q5TFF4 Q9Y264 B4E3J9
|
| Accessions |
CAK96135 CAK96155 EAX10654 Q9Y264 AF074332 AAD31728 AF113708 AAD21587 AK304756 BAG65511 BC111922 AAI11923 BC111976 AAI11977 BC111978 AAI11979 BC118495 AAI18496 XM_005260720 XP_005260777 XM_006723567 XP_006723630 XM_011529239 XP_011527541 XM_011529240 XP_011527542 XM_011529241 XP_011527543 XM_011529242 XP_011527544 XM_011529243 XP_011527545 NM_015985 NP_057069
|
| Function |
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269|PubMed:15284220}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in the lung with much lower levels found in other tissues.
|
| Top Pathways |
PI3K-Akt signaling pathway, Rap1 signaling pathway
|
![Western Blot: Angiopoietin 4 Overexpression Lysate (Adult Normal) [NBP2-07100] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Angiopoietin 4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8471_Angiopoietin%25204%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07100-img0001.jpg)