Gene Symbol | ANGPT4 |
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Entrez Gene | 51378 |
Alt Symbol | AGP4, ANG-3, ANG4 |
Species | Human |
Gene Type | protein-coding |
Description | angiopoietin 4 |
Other Description | ANG-4|angiopoietin-3|angiopoietin-4|dJ824F16.2 (angiopoietin 4) |
Swissprots | Q9H4Z4 Q5TFF4 Q9Y264 B4E3J9 |
Accessions | CAK96135 CAK96155 EAX10654 Q9Y264 AF074332 AAD31728 AF113708 AAD21587 AK304756 BAG65511 BC111922 AAI11923 BC111976 AAI11977 BC111978 AAI11979 BC118495 AAI18496 XM_005260720 XP_005260777 XM_006723567 XP_006723630 XM_011529239 XP_011527541 XM_011529240 XP_011527542 XM_011529241 XP_011527543 XM_011529242 XP_011527544 XM_011529243 XP_011527545 NM_015985 NP_057069 |
Function | Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269|PubMed:15284220}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Highly expressed in the lung with much lower levels found in other tissues. |
Top Pathways | PI3K-Akt signaling pathway, Rap1 signaling pathway |
Ang-4 CRISPR/Cas9 KO Plasmid (h) - sc-409454 from Santa Cruz Biotechnology
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Ang-4 HDR Plasmid (h) - sc-409454-HDR from Santa Cruz Biotechnology
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Ang-4 Double Nickase Plasmid (h) - sc-409454-NIC from Santa Cruz Biotechnology
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Ang-4 Double Nickase Plasmid (h2) - sc-409454-NIC-2 from Santa Cruz Biotechnology
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Ang-4 CRISPR Activation Plasmid (h) - sc-409454-ACT from Santa Cruz Biotechnology
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Ang-4 CRISPR Activation Plasmid (h2) - sc-409454-ACT-2 from Santa Cruz Biotechnology
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Ang-4 Lentiviral Activation Particles (h) - sc-409454-LAC from Santa Cruz Biotechnology
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Ang-4 Lentiviral Activation Particles (h2) - sc-409454-LAC-2 from Santa Cruz Biotechnology
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Ang-4 siRNA (h) - sc-39309 from Santa Cruz Biotechnology
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Ang-4 shRNA Plasmid (h) - sc-39309-SH from Santa Cruz Biotechnology
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Ang-4 shRNA (h) Lentiviral Particles - sc-39309-V from Santa Cruz Biotechnology
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Angiopoietin-4 RNAi - H00051378-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3148 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01689 from Sigma-Aldrich
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ANGPT4 siRNA (Human) - CRH9734 from Cohesion Biosciences
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ANGPT4 - MBS8233234 from MyBioSource
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shRNA set against Human ANGPT4 (NM_015985.2) - SHH236250 from Creative biogene
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shRNA set against Human ANGPT4(NM_015985.2) - SHG057633 from Creative biogene
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Human ANGPT4 siRNA - orb270236 from Biorbyt
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ANGPT4 shRNA Plasmid (Human) - CHH9734 from Cohesion Biosciences
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ANGPT4 miRNA 3'UTR clone - MiUTR1H-00361 from Creative biogene
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