Gene Symbol | ANGPT4 |
---|---|
Entrez Gene | 51378 |
Alt Symbol | AGP4, ANG-3, ANG4 |
Species | Human |
Gene Type | protein-coding |
Description | angiopoietin 4 |
Other Description | ANG-4|angiopoietin-3|angiopoietin-4|dJ824F16.2 (angiopoietin 4) |
Swissprots | Q9H4Z4 Q5TFF4 Q9Y264 B4E3J9 |
Accessions | CAK96135 CAK96155 EAX10654 Q9Y264 AF074332 AAD31728 AF113708 AAD21587 AK304756 BAG65511 BC111922 AAI11923 BC111976 AAI11977 BC111978 AAI11979 BC118495 AAI18496 XM_005260720 XP_005260777 XM_006723567 XP_006723630 XM_011529239 XP_011527541 XM_011529240 XP_011527542 XM_011529241 XP_011527543 XM_011529242 XP_011527544 XM_011529243 XP_011527545 NM_015985 NP_057069 |
Function | Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269|PubMed:15284220}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Highly expressed in the lung with much lower levels found in other tissues. |
Top Pathways | PI3K-Akt signaling pathway, Rap1 signaling pathway |