EFEMP1
| Gene Symbol | EFEMP1 |
|---|---|
| Entrez Gene | 2202 |
| Alt Symbol | DHRD, DRAD, FBLN3, FBNL, FIBL-3, MLVT, MTLV, S1-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EGF containing fibulin-like extracellular matrix protein 1 |
| Other Description | EGF-containing fibulin-like extracellular matrix protein 1|extracellular protein S1-5|fibulin-3 |
| Swissprots | D6W5D2 B4DW75 A8K3I4 Q12805 Q541U7 |
| Accessions | AAK11491 AAX81993 AAY14669 CAJ30876 EAX00080 EAX00081 EAX00082 Q12805 AA704122 AB209212 BAD92449 AI472137 AK092854 BAG52615 AK290599 BAF83288 AK293058 BAF85747 AK301402 BAG62937 AK301531 BAG63032 AK312639 BAG35523 AL703474 BC014410 AAH14410 BC098561 AAH98561 BU542044 BU683304 BX475672 DA264704 DQ892514 ABM83440 DQ895728 ABM86654 U03877 AAA65590 XM_005264205 XP_005264262 NM_001039348 NP_001034437 NM_001039349 NP_001034438 NM_004105 |
| Function | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. {ECO:0000269|PubMed:19804359, ECO:0000269|PubMed:19887559, ECO:0000269|PubMed:20005202}. |
| Subcellular Location | Secreted, extracellular space {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Localizes to the lamina propria underneath the olfactory epithelium. {ECO:0000250}. |
| Tissue Specificity | In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina. {ECO:0000269|PubMed:12242346, ECO:0000269|PubMed:20005202}. |
Fibulin-3 CRISPR/Cas9 KO Plasmid (h) - sc-401978 from Santa Cruz Biotechnology
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Fibulin-3 HDR Plasmid (h) - sc-401978-HDR from Santa Cruz Biotechnology
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Fibulin-3 Double Nickase Plasmid (h) - sc-401978-NIC from Santa Cruz Biotechnology
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Fibulin-3 Double Nickase Plasmid (h2) - sc-401978-NIC-2 from Santa Cruz Biotechnology
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Fibulin-3 CRISPR Activation Plasmid (h) - sc-401978-ACT from Santa Cruz Biotechnology
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Fibulin-3 CRISPR Activation Plasmid (h2) - sc-401978-ACT-2 from Santa Cruz Biotechnology
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Fibulin-3 Lentiviral Activation Particles (h) - sc-401978-LAC from Santa Cruz Biotechnology
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Fibulin-3 Lentiviral Activation Particles (h2) - sc-401978-LAC-2 from Santa Cruz Biotechnology
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Fibulin-3 siRNA (h) - sc-44624 from Santa Cruz Biotechnology
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Fibulin-3 shRNA Plasmid (h) - sc-44624-SH from Santa Cruz Biotechnology
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Fibulin-3 shRNA (h) Lentiviral Particles - sc-44624-V from Santa Cruz Biotechnology
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Fibulin-3/EFEMP1 RNAi - H00002202-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7685 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7685 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07902 from Sigma-Aldrich
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EFEMP1 siRNA (Human) - CRH1537 from Cohesion Biosciences
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Fibulin-3/EFEMP1 RNAi - H00002202-R02 from Novus Biologicals
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EFEMP1 - MBS8205544 from MyBioSource
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Fibulin-3 CRISPR/Cas9 KO Plasmid (h2) - sc-401978-KO-2 from Santa Cruz Biotechnology
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Fibulin-3 HDR Plasmid (h2) - sc-401978-HDR-2 from Santa Cruz Biotechnology
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Human EFEMP1 siRNA - orb262039 from Biorbyt
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EFEMP1 shRNA Plasmid (Human) - CHH1537 from Cohesion Biosciences
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EFEMP1 miRNA 3'UTR clone - MiUTR3H-04202 from Creative biogene
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EFEMP1 miRNA 3'UTR clone - MiUTR3H-04203 from Creative biogene
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