| Gene Symbol |
AGXT2
|
| Entrez Gene |
64902
|
| Alt Symbol |
AGT2, DAIBAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alanine--glyoxylate aminotransferase 2
|
| Other Description |
(R)-3-amino-2-methylpropionate--pyruvate transaminase|alanine--glyoxylate aminotransferase 2, mitochondrial|beta-ALAAT II|beta-alanine-pyruvate aminotransferase
|
| Swissprots |
Q5W7Q1 Q53G03 B7ZM47 Q9BYV1 Q53FB4 Q53FY7 E9PDL7
|
| Accessions |
EAW55912 Q9BYV1 AB193309 BAD66662 AJ292204 CAC24841 AK055732 BAG51563 AK055757 BAG51568 AK223128 BAD96848 AK223144 AK223375 BAD97095 AK296109 BAH12259 AK314691 BAG37242 BC144268 AAI44269 BC150603 AAI50604 BC156124 AAI56125 BC156919 AAI56920 BP277413 DA633665 XM_005248337 XP_005248394 XM_005248338 XP_005248395 XM_011514077 XP_011512379 XM_011514078 XP_011512380 NM_001306173 NP_001293102 NM_031900 NP_114106
|
| Function |
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:23023372}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:20018850}.
|
| Top Pathways |
Glycine, serine and threonine metabolism, Alanine, aspartate and glutamate metabolism
|
![Western Blot: AGXT2 Overexpression Lysate (Adult Normal) [NBP2-06106] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AGXT2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1879_AGXT2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06106-img0001.jpg)