Gene Symbol | AGXT2 |
---|---|
Entrez Gene | 64902 |
Alt Symbol | AGT2, DAIBAT |
Species | Human |
Gene Type | protein-coding |
Description | alanine--glyoxylate aminotransferase 2 |
Other Description | (R)-3-amino-2-methylpropionate--pyruvate transaminase|alanine--glyoxylate aminotransferase 2, mitochondrial|beta-ALAAT II|beta-alanine-pyruvate aminotransferase |
Swissprots | Q5W7Q1 Q53G03 B7ZM47 Q9BYV1 Q53FB4 Q53FY7 E9PDL7 |
Accessions | EAW55912 Q9BYV1 AB193309 BAD66662 AJ292204 CAC24841 AK055732 BAG51563 AK055757 BAG51568 AK223128 BAD96848 AK223144 AK223375 BAD97095 AK296109 BAH12259 AK314691 BAG37242 BC144268 AAI44269 BC150603 AAI50604 BC156124 AAI56125 BC156919 AAI56920 BP277413 DA633665 XM_005248337 XP_005248394 XM_005248338 XP_005248395 XM_011514077 XP_011512379 XM_011514078 XP_011512380 NM_001306173 NP_001293102 NM_031900 NP_114106 |
Function | Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:23023372}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:20018850}. |
Top Pathways | Glycine, serine and threonine metabolism, Alanine, aspartate and glutamate metabolism |
AGXT2 CRISPR/Cas9 KO Plasmid (h) - sc-413054 from Santa Cruz Biotechnology
|
||||||||
AGXT2 HDR Plasmid (h) - sc-413054-HDR from Santa Cruz Biotechnology
|
||||||||
AGXT2 Double Nickase Plasmid (h) - sc-413054-NIC from Santa Cruz Biotechnology
|
||||||||
AGXT2 Double Nickase Plasmid (h2) - sc-413054-NIC-2 from Santa Cruz Biotechnology
|
||||||||
AGXT2 CRISPR Activation Plasmid (h) - sc-413054-ACT from Santa Cruz Biotechnology
|
||||||||
AGXT2 CRISPR Activation Plasmid (h2) - sc-413054-ACT-2 from Santa Cruz Biotechnology
|
||||||||
AGXT2 Lentiviral Activation Particles (h) - sc-413054-LAC from Santa Cruz Biotechnology
|
||||||||
AGXT2 Lentiviral Activation Particles (h2) - sc-413054-LAC-2 from Santa Cruz Biotechnology
|
||||||||
AGXT2 siRNA (h) - sc-91787 from Santa Cruz Biotechnology
|
||||||||
AGXT2 shRNA Plasmid (h) - sc-91787-SH from Santa Cruz Biotechnology
|
||||||||
AGXT2 shRNA (h) Lentiviral Particles - sc-91787-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU018941 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2963 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2963 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR05426 from Sigma-Aldrich
|
||||||||
AGXT2 siRNA (Human) - CRJ2136 from Cohesion Biosciences
|
||||||||
AGXT2 - MBS8234160 from MyBioSource
|
||||||||
shRNA set against Human AGXT2 (NM_031900.3) - SHH233566 from Creative biogene
|
||||||||
AGXT2 shRNA Plasmid (Human) - CHJ2136 from Cohesion Biosciences
|
||||||||
AGXT2 miRNA 3'UTR clone - MiUTR3H-12455 from Creative biogene
|