| Gene Symbol |
SLC9A3R1
|
| Entrez Gene |
9368
|
| Alt Symbol |
EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
|
| Other Description |
Na(+)/H(+) exchange regulatory cofactor NHE-RF1|Na+/H+ exchange regulatory co-factor|ezrin-radixin-moesin binding phosphoprotein-50|ezrin-radixin-moesin-binding phosphoprotein 50|regulatory cofactor of Na(+)/H(+) exchanger|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1|solute carrier family 9 isoform A3 regulatory factor 1
|
| Swissprots |
Q86WQ5 O43552 B3KY21 O14745
|
| Accessions |
EAW89189 EAW89190 EAW89191 O14745 AF015926 AAC52084 AF036241 AAC04572 AI203594 AK026581 AK094467 BAG52871 AK128474 BAG54683 AK312498 BAG35400 BC001443 AAH01443 BC003361 AAH03361 BC011777 AAH11777 BC049220 AAH49220 BC053350 AAH53350 BP347679 BX648303 CN286501 CX761192 NM_004252 NP_004243
|
| Function |
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T- cells. {ECO:0000250}.
|
| Tissue Specificity |
Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. {ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9314537}.
|