SLC9A3R1

Gene Symbol	SLC9A3R1
Entrez Gene	9368
Alt Symbol	EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2
Species	Human
Gene Type	protein-coding
Description	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Other Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF1|Na+/H+ exchange regulatory co-factor|ezrin-radixin-moesin binding phosphoprotein-50|ezrin-radixin-moesin-binding phosphoprotein 50|regulatory cofactor of Na(+)/H(+) exchanger|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1|solute carrier family 9 isoform A3 regulatory factor 1
Swissprots	Q86WQ5 O43552 B3KY21 O14745
Accessions	EAW89189 EAW89190 EAW89191 O14745 AF015926 AAC52084 AF036241 AAC04572 AI203594 AK026581 AK094467 BAG52871 AK128474 BAG54683 AK312498 BAG35400 BC001443 AAH01443 BC003361 AAH03361 BC011777 AAH11777 BC049220 AAH49220 BC053350 AAH53350 BP347679 BX648303 CN286501 CX761192 NM_004252 NP_004243
Function	Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}.
Subcellular Location	Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T- cells. {ECO:0000250}.
Tissue Specificity	Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. {ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9314537}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EBP50 peptide - ab174779 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

EBP50 peptide - ab45974 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human EBP50 full length protein - ab112385 from Abcam Category Protein Source Wheat germ Species Human

Human EBP50 peptide - ab100816 from Abcam Category Peptide

Human EBP50 protein fragment - ab152975 from Abcam Category Protein Source Wheat germ Species Human

SLC9A3R1 / NHERF1 / EBP50 Antibody Blocking Peptide - LS-E8005 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NHERF-1 Protein - H00009368-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NHERF-1 Recombinant Protein - H00009368-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SLC9A3R1-Antibody-Center-Blocking-peptide - BP5853c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NHERF1 Blocking Peptide - 33R-10786 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

SLC9A3R1 / NHERF - H00009368-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SLC9A3R1 / NHERF - H00009368-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SLC9A3R1 / NHERF - H00009368-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SLC9A3R1 / NHERF - H00009368-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3 Regulator 1, His-tagged - SLC9A3R1-2912H from Creative Biomart Category Protein

Recombinant Human SLC9A3R1 - SLC9A3R1-28223TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Na(+)/H(+) exchange regulatory cofactor NHE-RF1(SLC9A3R1) - CSB-YP021733HU CSB-EP021733HU CSB-BP021733HU CSB-MP021733HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SLC9A3R1 / NHERF - TP301653 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NHERF-1 Recombinant Protein Antigen - NBP1-84919PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NHERF-1 Recombinant Protein Antigen - NBP1-84918PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SLC9A3R1 Peptide, Human - M34GP14659H from Creative Peptides Category Peptide Source Synthetic. Species Human

Na (+) /H (+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1), Recombinant Protein - MBS1263385 from MyBioSource Category Protein Prices $1,120.00, $1,120.00, $1,355.00, $1,355.00, $1,780.00, $1,780.00, $2,245.00, $2,245.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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