SNX2

Gene Symbol	SNX2
Entrez Gene	6643
Alt Symbol	TRG-9
Species	Human
Gene Type	protein-coding
Description	sorting nexin 2
Other Description	CTB-36H16.2|sorting nexin-2|transformation-related gene 9 protein
Swissprots	Q9BTS8 Q597H6 Q53XK8 P82862 B4DEK4 O43650 B7Z408 O60749 B3KN44
Accessions	EAW48883 EAW48884 O60749 AF043453 AAB99852 AF065482 AAC17181 AK002170 BAG51023 AK023581 BAG51206 AK023716 BAG51219 AK026718 AK222968 BAD96688 AK293671 BAG57115 AK296596 BAH12394 AY272044 AAQ02693 BC003382 AAH03382 BT009841 AAP88843 DA738311 DC313082 DC338761 DQ890933 ABM81859 DQ894096 ABM85022 HG498411 NM_001278199 NP_001265128 NM_003100 NP_003091
Function	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity
Subcellular Location	Early endosome membrane {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Peripheral membrane protein {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Cytoplasmic side {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNX2 (F-8) - sc-390510 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SNX2 (N-17) - sc-10613 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX2 (L-16) - sc-10616 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX2 (Q-18) - sc-10614 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX2 (H-188) - sc-366198 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SNX2 (13) - sc-136072 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-SNX2 antibody - ab26201 from Abcam Prices $406.00 Sizes 50 µg Host Chicken Clonality Polyclonal

Anti-SNX2 antibody - ab134039 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485) - LS-C161367 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485, AP) - LS-C269881 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485, APC) - LS-C269882 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485, Biotin) - LS-C269883 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485, Azide-free, HRP) - LS-C269885 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485, FITC) - LS-C269884 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa457-485, PE) - LS-C269887 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa456-485) - LS-C325253 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (C-Terminus) - LS-C151748 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa120-170) IHC-plus™ - LS-B7215 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX2 Antibody (aa350-400) IHC-plus™ - LS-B7232 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

SNX2 Antibody - NBP2-24513 from Novus Biologicals Prices $269.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

SNX2 Antibody - NBP2-24514 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

SNX2 Antibody - NBP1-89485 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX2 Antibody - NBP2-20445 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX2 Antibody - NBP1-03404 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX2 Polyclonal Antibody - bs-12249R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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