SNX2

Gene Symbol SNX2
Entrez Gene 6643
Alt Symbol TRG-9
Species Human
Gene Type protein-coding
Description sorting nexin 2
Other Description CTB-36H16.2|sorting nexin-2|transformation-related gene 9 protein
Swissprots Q9BTS8 Q597H6 Q53XK8 P82862 B4DEK4 O43650 B7Z408 O60749 B3KN44
Accessions EAW48883 EAW48884 O60749 AF043453 AAB99852 AF065482 AAC17181 AK002170 BAG51023 AK023581 BAG51206 AK023716 BAG51219 AK026718 AK222968 BAD96688 AK293671 BAG57115 AK296596 BAH12394 AY272044 AAQ02693 BC003382 AAH03382 BT009841 AAP88843 DA738311 DC313082 DC338761 DQ890933 ABM81859 DQ894096 ABM85022 HG498411 NM_001278199 NP_001265128 NM_003100 NP_003091
Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity
Subcellular Location Early endosome membrane {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Peripheral membrane protein {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Cytoplasmic side {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.

SNX2 CRISPR/Cas9 KO Plasmid (h) - sc-404625 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 HDR Plasmid (h) - sc-404625-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 Double Nickase Plasmid (h) - sc-404625-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 Double Nickase Plasmid (h2) - sc-404625-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 CRISPR Activation Plasmid (h) - sc-404625-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 CRISPR Activation Plasmid (h2) - sc-404625-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 Lentiviral Activation Particles (h) - sc-404625-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 Lentiviral Activation Particles (h2) - sc-404625-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX2 siRNA (h) - sc-41349 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SNX2 shRNA Plasmid (h) - sc-41349-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SNX2 shRNA (h) Lentiviral Particles - sc-41349-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SNX2 siRNA (T. guttata) - sc-270110 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm

SNX2 shRNA Plasmid (T. guttata) - sc-270110-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm

SNX2 RNAi - H00006643-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU102711 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20298 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03990 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03990

SNX2 siRNA (Human) - CRH4524 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SNX2 - MBS8216362 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SNX2 (NM_003100.2) - SHH414680 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SNX2(NM_003100.2) - SHL023688 from Creative biogene

Category siRNA
Species Reactivities Human

Human SNX2 siRNA - orb265026 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SNX2 shRNA Plasmid (Human) - CHH4524 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SNX2 miRNA 3'UTR clone - MiUTR1H-09715 from Creative biogene

Species Reactivities Human
Search more