SNX2

Gene Symbol SNX2
Entrez Gene 6643
Alt Symbol TRG-9
Species Human
Gene Type protein-coding
Description sorting nexin 2
Other Description CTB-36H16.2|sorting nexin-2|transformation-related gene 9 protein
Swissprots Q9BTS8 Q597H6 Q53XK8 P82862 B4DEK4 O43650 B7Z408 O60749 B3KN44
Accessions EAW48883 EAW48884 O60749 AF043453 AAB99852 AF065482 AAC17181 AK002170 BAG51023 AK023581 BAG51206 AK023716 BAG51219 AK026718 AK222968 BAD96688 AK293671 BAG57115 AK296596 BAH12394 AY272044 AAQ02693 BC003382 AAH03382 BT009841 AAP88843 DA738311 DC313082 DC338761 DQ890933 ABM81859 DQ894096 ABM85022 HG498411 NM_001278199 NP_001265128 NM_003100 NP_003091
Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity
Subcellular Location Early endosome membrane {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Peripheral membrane protein {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Cytoplasmic side {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.

Human SNX2 full length protein - ab159556 from Abcam

Category Protein
Source Wheat germ
Species Human
ab159556 on a 12.5% SDS-PAGE stained with Coomassie Blue.

SNX2 Antibody Blocking Peptide - LS-E3936 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SNX2 Antibody Blocking Peptide - LS-E23532 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SNX2 Recombinant Protein - H00006643-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Species Human

SNX2-Antibody-C-term-Blocking-Peptide - BP16134b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Sorting nexin-2 (SNX2) - H00006643-P01-02 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Source in vitro transl.
Species Human

Recombinant Human Sorting Nexin 2/SNX2, Transfected HEK293 Cell Lysate - 230-10089-100 from RayBiotech

Category Protein
Prices $153.50
Sizes 100 µg
Source Human Embryonic Kidney 293 (HEK293) Cells
Species Human

Recombinant Human SNX2, Transfected HEK293 Cell Culture Supernatant - 230-20056-200 from RayBiotech

Category Protein
Prices $102.00
Sizes 200 µl
Source Human Embryonic Kidney 293 (HEK293) Cells
Species Human

SNX2 fusion protein - ag2259 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Sorting nexin-2(SNX2) - CSB-YP022365HU CSB-EP022365HU CSB-BP022365HU CSB-MP022365HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Sorting nexin-2 (SNX2) - TP301621 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Sorting nexin-2 (SNX2)

Human Sorting Nexin 2, Transfected HEK293 Cell Lysate - orb305121 from Biorbyt

Category Protein
Prices $289.00
Sizes 100 μg
Species Human

Human SNX2 protein - orb305160 from Biorbyt

Category Protein
Prices $238.00
Sizes 200 μl
Species Human

SNX2 Recombinant Protein Antigen - NBP1-89485PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

SNX2 Peptide, Human - M34GP14852H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Sorting nexin-2 (SNX2), Recombinant Protein - MBS1039936 from MyBioSource

Category Protein
Prices $1,310.00, $1,310.00, $1,530.00, $1,530.00, $2,155.00, $2,155.00, $2,620.00, $2,620.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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