| Gene Symbol |
AGO4
|
| Entrez Gene |
192670
|
| Alt Symbol |
EIF2C4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
argonaute RISC catalytic component 4
|
| Other Description |
argonaute 4|argonaute4|eIF-2C 4|eIF2C 4|eukaryotic translation initiation factor 2C, 4|hAgo4|protein argonaute-4
|
| Swissprots |
A7MD27 Q9HCK5
|
| Accessions |
EAX07398 EAX07399 EAX07400 Q9HCK5 AB046787 BAB13393 AK000040 BAA90899 AL831908 BC152450 AAI52451 BC160021 AAI60021 BG186585 CA419947 XM_005270578 XP_005270635 XM_005270579 XP_005270636 XM_011540883 XP_011539185 XM_011540884 XP_011539186 XR_246243 XR_246244 XR_946567 NM_017629 NP_060099
|
| Function |
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). {ECO:0000255|HAMAP- Rule:MF_03033, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:18552826, ECO:0000269|PubMed:18771919}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03033, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:19167051}.
|