SSB

Gene Symbol SSB
Entrez Gene 6741
Alt Symbol LARP3, La, La/SSB
Species Human
Gene Type protein-coding
Description Sjogren syndrome antigen B (autoantigen La)
Other Description La ribonucleoprotein domain family, member 3|SS-B|SS-B/La protein|autoantigen La|la autoantigen|lupus La antigen|lupus La protein|sjoegren syndrome type B antigen
Swissprots Q53XJ4 P05455 Q15367
Accessions AAY14868 EAX11256 EAX11257 EAX11258 EAX11259 P05455 AB451228 BAG70042 AB451351 BAG70165 AK124811 BC001289 AAH01289 BC020818 AAH20818 BT009862 AAP88864 CD676196 D28394 BAA05760 DQ185046 ABD14426 DQ894459 ABM85385 J04205 AAA51885 M20328 AAA36577 M35261 AAA36652 M35262 AAA36654 M35263 AAA36653 S57806 S57808 X13697 CAA31985 X14684 CAA32815 X69804 NM_001294145 NP_001281074 NM_003142 NP_003133
Function Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. {ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}.
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Systemic lupus erythematosus

La Antigen Antibody - 2081 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using La Antigen Antibody.

La Antigen (D19B3) Rabbit mAb - 5034 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D19B3
Western blot analysis of extracts from various cell types using La Antigen (D19B3) Rabbit mAb.

La/SSB (B-8) - sc-166274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
La/SSB (B-8): sc-166274. Western blot analysis of La/SSB expression in non-transfected 293T: sc-117752 (A), mouse La/SSB transfected 293T: sc-127079 (B) and Ramos (C) whole cell lysates.

La/SSB (312B) - sc-80656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
La/SSB (312B): sc-80656. Western blot analysis of La/SSB expression in Ramos (A) and NAMALWA (B) whole cell lysates.

La/SSB (N-20) - sc-21391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
La/SSB (N-20): sc-21391. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing nuclear and cytoplasmic staining of glandular cells.

La/SSB (22A) - sc-80655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
La/SSB (22A): sc-80655. Western blot analysis of La/SSB expression in Ramos (A) and NAMALWA (B) whole cell lysates.

La/SSB (D-20) - sc-21393 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
La/SSB (D-20): sc-21393. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing nuclear and cytoplasmic staining of glandular cells.

La/SSB (H-300) - sc-33593 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
La/SSB (H-300): sc-33593. Western blot analysis of La/SSB expression in Ramos (A) and NAMALWA (B) whole cell lysates.

La/SSB (44) - sc-136258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
La/SSB (44): sc-136258. Immunofluorescence staining of HeLa cells showing nuclear localization.

Anti-SSB (phospho S366) antibody - ab61800 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of SSB (phospho S366) staining in Human breast adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab61800, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-SSB antibody - ab154998 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SSB antibody (ab154998) at 1/1000 dilution + 293T whole cell lysate at 30 µg

Anti-SSB antibody - ab133171 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SSB antibody (ab133171) at 1/500 dilutionLane 1 : COLO cell extractLane 2 : COLO cell extract with synthesized peptide

Anti-SSB antibody - ab61779 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SSB antibody (ab61779) at 1/500 dilutionLane 1 : 293 cell extractsLane 2 : 293 cell extracts with immunising peptide

Anti-SSB antibody [EPR6570] - ab124932 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6570
All lanes : Anti-SSB antibody [EPR6570] (ab124932) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : HeLa cell lysateLane 4 : Ramos cell lysateLane 5 : C6 cell lysateLane 6 : PC12 cell lysateLane 7 : NIH 3T3 cell lysateLane 8 : RAW 264.7 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti Rabbit at 1/2000 dilution

Anti-SSB antibody [mAbcam75927] - ab75927 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam75927
IHC image of SSB staining in Human breast adenocarcinoma formalin fixed paraffin embedded tissue section*. The section was pre-treated using pressure cooker heat mediated antigen retrieval with sodium citrate buffer (pH6) for 30mins. The section was incubated with ab75927, 0.5µg/ml overnight at +4°C. An HRP-conjugated secondary (Ab97245, 1/200 dilution) was used for 1hr at room temperature. The section was counterstained with haematoxylin and mounted with DPX.*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre

Anti-SSB antibody [mAbcam75927] (HRP) - ab196720 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone mAbcam75927
IHC image of SSB staining in a section of formalin-fixed paraffin-embedded normal human colon*, performed on a Leica BOND. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab196720 at 1/100 dilution, for 15 mins at room temperature. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre

Anti-SSB antibody - C-terminal - ab79859 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SSB antibody - C-terminal (ab79859) at 1/50 dilution + HeLa cell line lysates at 35 µg

Anti-SSB / La Antibody - LS-C8426 from LifeSpan Bioscience

Prices $335.00
Sizes 2 ml
Host Human
Clonality Polyclonal

Anti-SSB / La Antibody - LS-C132124 from LifeSpan Bioscience

Prices $375.00
Sizes 2 ml
Host Human
Clonality Polyclonal

Anti-SSB / La Antibody (aa171-220) - LS-C80336 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.

Anti-SSB / La Antibody (clone 1D6-H5) - LS-C133450 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D6-H5
SSB monoclonal antibody (M01), clone 1D6-H5 Western blot of SSB expression in HL-60.

Anti-SSB / La Antibody (Thr362) - LS-C191898 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SSB / La Antibody (clone La4B6) - LS-C193331 from LifeSpan Bioscience

Prices $800.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone La4B6

Anti-SSB / La Antibody (C-Terminus) - LS-C97289 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SSB Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SSB / La Antibody (aa50-100) - LS-C290551 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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