Gene Symbol | SSB |
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Entrez Gene | 6741 |
Alt Symbol | LARP3, La, La/SSB |
Species | Human |
Gene Type | protein-coding |
Description | Sjogren syndrome antigen B (autoantigen La) |
Other Description | La ribonucleoprotein domain family, member 3|SS-B|SS-B/La protein|autoantigen La|la autoantigen|lupus La antigen|lupus La protein|sjoegren syndrome type B antigen |
Swissprots | Q53XJ4 P05455 Q15367 |
Accessions | AAY14868 EAX11256 EAX11257 EAX11258 EAX11259 P05455 AB451228 BAG70042 AB451351 BAG70165 AK124811 BC001289 AAH01289 BC020818 AAH20818 BT009862 AAP88864 CD676196 D28394 BAA05760 DQ185046 ABD14426 DQ894459 ABM85385 J04205 AAA51885 M20328 AAA36577 M35261 AAA36652 M35262 AAA36654 M35263 AAA36653 S57806 S57808 X13697 CAA31985 X14684 CAA32815 X69804 NM_001294145 NP_001281074 NM_003142 NP_003133 |
Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. {ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Systemic lupus erythematosus |
La/SSB CRISPR/Cas9 KO Plasmid (h) - sc-416582 from Santa Cruz Biotechnology
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La/SSB HDR Plasmid (h) - sc-416582-HDR from Santa Cruz Biotechnology
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La/SSB Double Nickase Plasmid (h) - sc-416582-NIC from Santa Cruz Biotechnology
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La/SSB Double Nickase Plasmid (h2) - sc-416582-NIC-2 from Santa Cruz Biotechnology
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La/SSB CRISPR Activation Plasmid (h) - sc-416582-ACT from Santa Cruz Biotechnology
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La/SSB CRISPR Activation Plasmid (h2) - sc-416582-ACT-2 from Santa Cruz Biotechnology
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La/SSB Lentiviral Activation Particles (h) - sc-416582-LAC from Santa Cruz Biotechnology
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La/SSB Lentiviral Activation Particles (h2) - sc-416582-LAC-2 from Santa Cruz Biotechnology
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La/SSB siRNA (h) - sc-40915 from Santa Cruz Biotechnology
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La/SSB shRNA Plasmid (h) - sc-40915-SH from Santa Cruz Biotechnology
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La/SSB shRNA (h) Lentiviral Particles - sc-40915-V from Santa Cruz Biotechnology
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SSB RNAi - H00006741-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20614 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20614 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01966 from Sigma-Aldrich
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SSB siRNA (Human) - CRH4605 from Cohesion Biosciences
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SSB - MBS8202820 from MyBioSource
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Human SSB siRNA - orb265107 from Biorbyt
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SSB shRNA Plasmid (Human) - CHH4605 from Cohesion Biosciences
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SSB miRNA 3'UTR clone - MiUTR3H-00229 from Creative biogene
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