EIF2AK2

Gene Symbol EIF2AK2
Entrez Gene 5610
Alt Symbol EIF2AK1, PKR, PPP1R83, PRKR
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 2-alpha kinase 2
Other Description P1/eIF-2A protein kinase|double stranded RNA activated protein kinase|eIF-2A protein kinase 2|interferon-induced, double-stranded RNA-activated protein kinase|interferon-inducible elF2alpha kinase|p68 kinase|protein kinase R|protein kinase, interferon-inducible double stranded RNA dependent|protein phosphatase 1, regulatory subunit 83|tyrosine-protein kinase EIF2AK2
Swissprots A8K3P0 P19525 E9PC80 Q7Z6F6 D6W584 Q9UIR4 Q52M43
Accessions AAC50768 AAF13156 AAO38055 AAY24317 EAX00406 EAX00407 EAX00408 EAX00409 P19525 AF086566 AI360504 AK290655 BAF83344 AK313818 BAG36554 AY302136 AAP57628 BC007769 AAH07769 BC022314 AAH22314 BC040851 AAH40851 BC057805 AAH57805 BC093676 AAH93676 BC101475 AAI01476 BC143228 BC143230 AAI43231 BM473760 BU687340 F03305 M35663 AAA36409 M85294 AAA18253 XM_011532987 XP_011531289 NM_001135651 NP_001129123 NM_001135652 NP_001129124 NM_002759 NP_002750
Function IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4'
Subcellular Location Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients.
Tissue Specificity Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression. {ECO:0000269|PubMed:21029237, ECO:0000269|PubMed:23403623}.
Top Pathways Protein processing in endoplasmic reticulum, Hepatitis C, Measles, Influenza A, Herpes simplex infection

Human EIF2AK2 / PKR ELISA Kit (Sandwich ELISA) - LS-F4650 from LifeSpan Bioscience

Category ELISA Kit
Prices $650.00
Sizes 1 plate
Sensitivity 0.059 ng/ml
Range 0.156-10 ng/ml

Human Phospho-EIF2AK2 / PKR (Thr258) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1698 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.156-10 ng/ml

Human Phospho-EIF2AK2 / PKR (Thr446) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1605 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.156-10 ng/ml

Human EIF2AK2 / PKR ELISA Kit (Cell-Based ELISA) - LS-F2257 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.156-10 ng/ml

Human EIF2AK2 / PKR ELISA Kit (Sandwich ELISA) - LS-F11338 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Interferon-induced, double-stranded RNA-activated protein kinase, EIF2AK2, Human, ELISA Kit - E1135h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.156-10 ng/mL

Protein Kinase R (PKR), Human, ELISA Kit - SEA520Hu from ARP American Research Products

Category ELISA Kit
Prices $650.00
Sizes 96 t
Sensitivity 0.055ng/mL
Range 0.156-10ng/mL

Inhibitor of Kb Kinase, ELISA Kit - MBS026631 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS065291 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS089880 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS027675 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS027176 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS036398 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS069183 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS008050 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS107392 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS040840 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS039561 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS024215 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Kb Kinase, ELISA Kit - MBS026528 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0ng/ml.
Range 3.12ng/ml-100ng/ml.

Inhibitor of Kb Kinase, ELISA Kit - MBS028073 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PKR Colorimetric Cell-Based ELISA Kit - CB5572 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PKR (Phospho-Thr446) Colorimetric Cell-Based ELISA Kit - CBP1659 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PKR (Phospho-Thr258) Colorimetric Cell-Based ELISA Kit - CBP1768 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Inhibitor of Kb Kinase, ELISA Kit - MBS045253 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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