| Gene Symbol | PLSCR3 |
|---|---|
| Entrez Gene | 57048 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipid scramblase 3 |
| Other Description | PL scramblase 3|ca(2+)-dependent phospholipid scramblase 3 |
| Swissprots | Q96F13 Q9NRY6 Q567U0 A8K252 Q8NBW6 |
| Accessions | CAF86478 EAW90198 EAW90200 EAW90202 Q9NRY6 AF159442 AAF91083 AF289602 AAL55786 AK075188 BAC11458 AK098229 AK124006 AK314643 BAG37205 BC011735 AAH11735 BC028080 BC093026 AAH93026 BG830095 CX785894 DQ893413 ABM84339 DQ896733 ABM87732 NM_001201576 NP_001188505 NM_020360 NP_065093 |
| Function | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. {ECO:0000269|PubMed:17226776}. |
| Subcellular Location | Mitochondrion membrane {ECO:0000269|PubMed:17226776}; Single-pass type II membrane protein {ECO:0000269|PubMed:17226776}. |
| Tissue Specificity | Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver. |