WNK3

Gene Symbol	WNK3
Entrez Gene	65267
Alt Symbol	PRKWNK3
Species	Human
Gene Type	protein-coding
Description	WNK lysine deficient protein kinase 3
Other Description	protein kinase with no lysine 3|serine/threonine-protein kinase WNK3
Swissprots	Q5JRC1 Q9BYP7 Q8TCX6 B1AKG2 Q6JP76 Q9HCK6
Accessions	EAW93175 EAW93176 Q9BYP7 AB046786 BAB13392 AJ409088 CAC32455 AK054999 AK124653 AY082340 AAL99253 AY352048 AAR89465 BC156469 AAI56470 R44257 Z44479 XM_006724593 XP_006724656 XM_011530802 XP_011529104 XM_011530803 XP_011529105 XM_011530804 XP_011529106 XM_011530805 XP_011529107 XM_011530806 XP_011529108 XM_011530807 XP_011529109 NM_001002838 NP_001002838 NM_020922 NP_065973
Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16501604}.
Tissue Specificity	Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain- specific. Isoform 3 is kidney-specific. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:15194194, ECO:0000269|PubMed:16275913}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

WNK3 (H-20) - sc-20471 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WNK3 (C-20) - sc-20473 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-WNK3 antibody - ab187503 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 antibody - ab192378 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WNK3 antibody - ab57690 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-WNK3 / PRKWNK3 Antibody - LS-C335585 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (aa1-50) - LS-C288656 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus, AP) - LS-C246396 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus, APC) - LS-C246397 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus, FITC) - LS-C246399 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus, Biotin) - LS-C246398 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus, PE) - LS-C246400 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus, Biotin) - LS-C246403 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus, APC) - LS-C246401 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus, AP) - LS-C246402 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus, FITC) - LS-C246404 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus, Azide-free, HRP) - LS-C247977 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus, Azide-free, HRP) - LS-C247976 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus, PE) - LS-C246405 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (C-Terminus) - LS-C329111 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (N-Terminus) - LS-C330737 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody - LS-C341665 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WNK3 / PRKWNK3 Antibody (aa431-480) - LS-C107647 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

WNK3 Antibody - NBP1-58361 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

WNK3 Antibody - NBP1-87226 from Novus Biologicals Host Rabbit Clonality Polyclonal

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