WNK3

Gene Symbol	WNK3
Entrez Gene	65267
Alt Symbol	PRKWNK3
Species	Human
Gene Type	protein-coding
Description	WNK lysine deficient protein kinase 3
Other Description	protein kinase with no lysine 3|serine/threonine-protein kinase WNK3
Swissprots	Q5JRC1 Q9BYP7 Q8TCX6 B1AKG2 Q6JP76 Q9HCK6
Accessions	EAW93175 EAW93176 Q9BYP7 AB046786 BAB13392 AJ409088 CAC32455 AK054999 AK124653 AY082340 AAL99253 AY352048 AAR89465 BC156469 AAI56470 R44257 Z44479 XM_006724593 XP_006724656 XM_011530802 XP_011529104 XM_011530803 XP_011529105 XM_011530804 XP_011529106 XM_011530805 XP_011529107 XM_011530806 XP_011529108 XM_011530807 XP_011529109 NM_001002838 NP_001002838 NM_020922 NP_065973
Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16501604}.
Tissue Specificity	Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain- specific. Isoform 3 is kidney-specific. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:15194194, ECO:0000269|PubMed:16275913}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human WNK3 protein fragment - ab163933 from Abcam Category Protein Source Wheat germ Species Human

WNK3 / PRKWNK3 Antibody Blocking Peptide - LS-E17544 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WNK3 Protein - H00065267-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WNK3 Blocking Peptide - 33R-10032 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WNK3 - H00065267-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WNK3 - H00065267-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

WNK3 - P5664 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

WNK3 Protein, active, 250 µg - 14-658M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-658) and in bulk (cat# 14-658-K) Source Expressed by baculovirus in Sf21 cells

Recombinant Human Serine/threonine-protein kinase WNK3(WNK3) ,partial - CSB-YP861176HU CSB-EP861176HU CSB-BP861176HU CSB-MP861176HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WNK3 Protein, active, 10 µg - 14-658 from EMD Millipore Category Protein Prices $329.00 Sizes 10 µg Source Expressed by baculovirus in Sf21 cells

WNK3-PRKWNK3-Antibody-C-term-Blocking-peptide - BP7054b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WNK3-PRKWNK3-Antibody-N-term-Blocking-peptide - BP7054a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WNK3 Peptide, Human - M34GP17509H from Creative Peptides Category Peptide Source Synthetic. Species Human

WNK3 Recombinant Protein Antigen - NBP2-57909PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Serine/threonine-protein kinase WNK3 (WNK3), partial, Recombinant Protein - MBS1370973 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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