| Gene Symbol |
WNK3
|
| Entrez Gene |
65267
|
| Alt Symbol |
PRKWNK3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WNK lysine deficient protein kinase 3
|
| Other Description |
protein kinase with no lysine 3|serine/threonine-protein kinase WNK3
|
| Swissprots |
Q5JRC1 Q9BYP7 Q8TCX6 B1AKG2 Q6JP76 Q9HCK6
|
| Accessions |
EAW93175 EAW93176 Q9BYP7 AB046786 BAB13392 AJ409088 CAC32455 AK054999 AK124653 AY082340 AAL99253 AY352048 AAR89465 BC156469 AAI56470 R44257 Z44479 XM_006724593 XP_006724656 XM_011530802 XP_011529104 XM_011530803 XP_011529105 XM_011530804 XP_011529106 XM_011530805 XP_011529107 XM_011530806 XP_011529108 XM_011530807 XP_011529109 NM_001002838 NP_001002838 NM_020922 NP_065973
|
| Function |
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16501604}.
|
| Tissue Specificity |
Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain- specific. Isoform 3 is kidney-specific. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:15194194, ECO:0000269|PubMed:16275913}.
|