Gene Symbol | NEU4 |
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Entrez Gene | 129807 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | sialidase 4 |
Other Description | N-acetyl-alpha-neuraminidase 4|neuraminidase 4|sialidase-4 |
Swissprots | Q96D64 J3KNJ5 A8K056 Q8WWR8 |
Accessions | AAX82022 EAW71294 EAW71295 EAW71296 EAW71297 Q8WWR8 AJ277883 CAC81904 AK025617 AK091038 BAG52266 AK096992 AK289421 BAF82110 AK290076 BAF82765 AK298403 BAH12778 AK300969 BAH13385 AY203952 AAP34475 BC012899 AAH12899 BC063465 BC067780 BC105974 AAI05975 BC117214 AAI17215 BQ651855 DB173219 DC412650 HQ258276 ADR83030 NM_001167599 NP_001161071 NM_001167600 NP_001161072 NM_001167601 NP_001161073 NM_001167602 NP_001161074 NM_080741 NP_542779 |
Function | May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. {ECO:0000269|PubMed:14962670, ECO:0000269|PubMed:15213228}. |
Subcellular Location | Isoform 1: Membrane; Peripheral membrane protein. |
Tissue Specificity | Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta. {ECO:0000269|PubMed:14962670}. |
Top Pathways | Sphingolipid metabolism, Other glycan degradation |
NEU4 Antibody Blocking Peptide - LS-E186 from LifeSpan Bioscience
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NEU4 Antibody Blocking Peptide - LS-E18895 from LifeSpan Bioscience
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NEU4-Antibody-C-term-Blocking-peptide - BP10385b from Abgent, a WuXi AppTec company
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NEU4 Blocking Peptide - 33R-9097 from Fitzgerald
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NEU4 fusion protein - ag18049 from Proteintech Group
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NEU4 fusion protein - Ag3657 from Proteintech Group
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Recombinant Human Sialidase-4(NEU4) - CSB-YP848831HU CSB-EP848831HU CSB-BP848831HU CSB-MP848831HU from Cusabio
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Sialidase-4 - TP303948 from Acris Antibodies
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NEU4 Recombinant Protein Antigen - NBP2-32682PEP from Novus Biologicals
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NEU4 Recombinant Protein Antigen - NBP1-86278PEP from Novus Biologicals
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NEU4 Peptide, Human - M34GP10309H from Creative Peptides
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Sialidase-4 (NEU4), Recombinant Protein - MBS1421132 from MyBioSource
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