| Gene Symbol | SMC6 |
|---|---|
| Entrez Gene | 79677 |
| Alt Symbol | SMC-6, SMC6L1, hSMC6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | structural maintenance of chromosomes 6 |
| Other Description | SMC protein 6|SMC6 structural maintenance of chromosomes 6-like 1|structural maintenance of chromosomes protein 6 |
| Swissprots | Q96SB8 A8K8Q6 Q9H6M0 Q05BV4 D6W518 Q9H0X3 |
| Accessions | AAX88851 EAX00866 EAX00867 EAX00868 Q96SB8 AJ310551 CAC39248 AK025769 BAB15236 AK092853 AK098325 AK124545 AK292421 BAF85110 AL136544 CAB66479 AL832979 CAH56327 AM392534 CAL37412 BC011389 BC022998 BC032675 AAH32675 BC039828 AAH39828 CD369665 DB451629 XM_011533107 XP_011531409 XM_011533108 XP_011531410 XR_939716 NM_001142286 NP_001135758 NM_024624 NP_078900 |
| Function | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526}. |
| Subcellular Location | Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. |
| Tissue Specificity | Widely expressed. Overexpressed in testis. {ECO:0000269|PubMed:11408570}. |
SMC6 CRISPR/Cas9 KO Plasmid (h) - sc-402805 from Santa Cruz Biotechnology
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SMC6 HDR Plasmid (h) - sc-402805-HDR from Santa Cruz Biotechnology
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SMC6 Double Nickase Plasmid (h) - sc-402805-NIC from Santa Cruz Biotechnology
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SMC6 Double Nickase Plasmid (h2) - sc-402805-NIC-2 from Santa Cruz Biotechnology
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SMC6 CRISPR Activation Plasmid (h) - sc-402805-ACT from Santa Cruz Biotechnology
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SMC6 CRISPR Activation Plasmid (h2) - sc-402805-ACT-2 from Santa Cruz Biotechnology
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SMC6 Lentiviral Activation Particles (h) - sc-402805-LAC from Santa Cruz Biotechnology
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SMC6 Lentiviral Activation Particles (h2) - sc-402805-LAC-2 from Santa Cruz Biotechnology
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SMC6 siRNA (h) - sc-61565 from Santa Cruz Biotechnology
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SMC6 shRNA Plasmid (h) - sc-61565-SH from Santa Cruz Biotechnology
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SMC6 shRNA (h) Lentiviral Particles - sc-61565-V from Santa Cruz Biotechnology
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SMC6L1 RNAi - H00079677-R01 from Novus Biologicals
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MISSION® esiRNA - EHU026931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19779 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19779 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10271 from Sigma-Aldrich
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SMC6 siRNA (Human) - CRJ2480 from Cohesion Biosciences
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SMC6 - MBS8222093 from MyBioSource
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shRNA set against Human Smc6 (NM_024624.5) - SHH413300 from Creative biogene
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SMC6 shRNA Plasmid (Human) - CHJ2480 from Cohesion Biosciences
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SMC6 miRNA 3'UTR clone - MiUTR3H-10575 from Creative biogene
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SMC6 miRNA 3'UTR clone - MiUTR3H-10576 from Creative biogene
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