SMC6

Gene Symbol	SMC6
Entrez Gene	79677
Alt Symbol	SMC-6, SMC6L1, hSMC6
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 6
Other Description	SMC protein 6\|SMC6 structural maintenance of chromosomes 6-like 1\|structural maintenance of chromosomes protein 6
Swissprots	Q96SB8 A8K8Q6 Q9H6M0 Q05BV4 D6W518 Q9H0X3
Accessions	AAX88851 EAX00866 EAX00867 EAX00868 Q96SB8 AJ310551 CAC39248 AK025769 BAB15236 AK092853 AK098325 AK124545 AK292421 BAF85110 AL136544 CAB66479 AL832979 CAH56327 AM392534 CAL37412 BC011389 BC022998 BC032675 AAH32675 BC039828 AAH39828 CD369665 DB451629 XM_011533107 XP_011531409 XM_011533108 XP_011531410 XR_939716 NM_001142286 NP_001135758 NM_024624 NP_078900
Function	Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. {ECO:0000269\|PubMed:16810316, ECO:0000269\|PubMed:17589526}.
Subcellular Location	Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Tissue Specificity	Widely expressed. Overexpressed in testis. {ECO:0000269\|PubMed:11408570}.

SMC6 (A-3) - sc-365742 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

SMC6 (A-3): sc-365742. Western blot analysis of SMC6 expression in HeLa nuclear extract.

SMC6 (H-228) - sc-134543 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

SMC6 (H-228): sc-134543. Western blot analysis of SMC6 expression in non-transfected: sc-117752 (A) and human SMC6 transfected: sc-115848 (B) 293T whole cell lysates.

SMC6 (K-19) - sc-47633 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SMC6 (K-19): sc-47633. Western blot analysis of SMC6 expression in non-transfected: sc-117752 (A) and mouse SMC6 transfected: sc-123650 (B) 293T whole cell lysates.

SMC6 (N-18) - sc-47634 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SMC6 (43-Q) - sc-101015 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

SMC6 (43-Q): sc-101015. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta tissue showing nuclear localization.

Anti-SMC6L1 antibody - ab18039 from Abcam

Prices	$390.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling SMC6L1 with ab18039 at 1/1000 (1µg/ml). Detection: DAB.

Anti-SMC6L1 antibody - ab155495 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMC6L1 antibody (ab155495) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

Anti-SMC6L1 antibody - ab57759 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

SMC6L1 antibody (ab57759) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-SMC6L1 antibody - ab86103 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab86103, at 1/250 dilution, staining SMC6L1 in formalin-fixed, paraffin-embedded human ovarian tumor tissue by Immunohistochemistry using DAB staining.

Anti-SMC6L1 antibody - ab133869 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMC6L1 antibody (ab133869) at 1 µg/ml + MCF7 cell lysate at 10 µg

Anti-SMC6 Antibody (C-Terminus) - LS-C91728 from LifeSpan Bioscience

Prices	$575.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SMC6 Antibody (aa1-110, Azide-free) - LS-C328787 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-SMC6 Antibody - LS-C332069 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SMC6 Antibody (C-Terminus) - LS-C151617 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SMC6 Antibody (C-Terminus) - LS-C286446 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human SMC6 by Immunohistochemistry. Sample: FFPE section of human breast tumor. Antibody: Affinity purified rabbit anti-SMC6 used at a dilution of 1:250.

Anti-SMC6 Antibody (clone 2E6) - LS-C133814 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2E6

Immunoperoxidase of monoclonal antibody to SMC6L1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]

Anti-SMC6 Antibody (C-Terminus) - LS-C287152 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human SMC6 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-SMC6 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

SMC6L1 Antibody - NB100-470 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SMC6L1 Antibody - NBP2-33378 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: SMC6L1 Antibody [NBP2-33378] - Staining of human colon shows moderate cytoplasmic and nuclear positivity in glandular cells.

SMC6L1 Antibody - NBP2-20420 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SMC6L1 Antibody [NBP2-20420] - Sample (30 ug of whole cell lysate) A: NT2D1 7. 5% SDS PAGE gel, diluted at 1:1000.

SMC6L1 Antibody (2E6) - H00079677-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2E6

Western Blot: SMC6L1 Antibody (2E6) [H00079677-M01] - SMC6L1 monoclonal antibody (M01), clone 2E6 Analysis of SMC6L1 expression in HeLa.

SMC6 Polyclonal Antibody - bs-7730R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Monoclonal Anti-SMC6L1 antibody produced in mouse - WH0079677M1 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2E6

<B>Immunoblotting</B><BR/>Monoclonal Anti-SMC6L1, <B>Cat. No. WH0079677M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~126.2 kDa using HeLa lysate.

Anti-SMC6 antibody produced in rabbit - HPA042733 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SMC6: <B>Cat. No. HPA042733</B>: Immunohistochemical staining of Human colon shows moderate cytoplasmic and nuclear positivity in glandular cells.

Anti-SMC6 antibody produced in rabbit - SAB2701298 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SMC6: <B>Cat. No. SAB2701298</B>: Immunohistochemical analysis of paraffin-embedded ES2 xenograft, using SMC6L1 antibody at 1:500 dilution.

Search more