SMC6

Gene Symbol	SMC6
Entrez Gene	79677
Alt Symbol	SMC-6, SMC6L1, hSMC6
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 6
Other Description	SMC protein 6|SMC6 structural maintenance of chromosomes 6-like 1|structural maintenance of chromosomes protein 6
Swissprots	Q96SB8 A8K8Q6 Q9H6M0 Q05BV4 D6W518 Q9H0X3
Accessions	AAX88851 EAX00866 EAX00867 EAX00868 Q96SB8 AJ310551 CAC39248 AK025769 BAB15236 AK092853 AK098325 AK124545 AK292421 BAF85110 AL136544 CAB66479 AL832979 CAH56327 AM392534 CAL37412 BC011389 BC022998 BC032675 AAH32675 BC039828 AAH39828 CD369665 DB451629 XM_011533107 XP_011531409 XM_011533108 XP_011531410 XR_939716 NM_001142286 NP_001135758 NM_024624 NP_078900
Function	Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526}.
Subcellular Location	Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Tissue Specificity	Widely expressed. Overexpressed in testis. {ECO:0000269|PubMed:11408570}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMC6L1 protein fragment - ab164073 from Abcam Category Protein Source Wheat germ Species Human

SMC6 Antibody Blocking Peptide - LS-E23369 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SMC6L1 Protein - H00079677-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMC6 - H00079677-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMC6 - H00079677-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMC6 fusion protein - Ag5812 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SMC6 fusion protein - ag6898 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human SMC6, GST-tagged - SMC6-2812H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Structural maintenance of chromosomes protein 6(SMC6) ,partial - CSB-YP836300HU CSB-EP836300HU CSB-BP836300HU CSB-MP836300HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMC6 (transcript variant 2) - TP308031 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SMC6L1 Recombinant Protein Antigen - NBP2-33378PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SMC6 Peptide, Human - M34GP14741H from Creative Peptides Category Peptide Source Synthetic. Species Human

SMC6L1 Recombinant Protein Antigen - NBP2-55146PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

Structural maintenance of chromosomes protein 6 (SMC6), partial, Recombinant Protein - MBS1468000 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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