SLC22A3

Gene Symbol SLC22A3
Entrez Gene 6581
Alt Symbol EMT, EMTH, OCT3
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation transporter), member 3
Other Description EMT organic cation transporter 3|extraneuronal monoamine transporter|organic cation transporter 3|solute carrier family 22 (extraneuronal monoamine transporter), member 3|solute carrier family 22 member 3
Swissprots Q9UP02 Q5SYN6 O75751
Accessions CAB96132 CAC39443 EAW47599 O75751 AF078749 AAD20977 AI810629 AJ001417 CAA04751 AK096980 AK125826 AK314590 BAG37164 BC070300 BC144280 BC156538 AAI56539 BC172500 AAI72500 BP320971 BX640965 XM_005267106 XP_005267163 XM_005267107 XP_005267164 XM_011536075 XP_011534377 XM_011536076 XP_011534378 XM_011536077 XP_011534379 XM_011536078 XP_011534380 XR_245546 NM_021977 NP_068812
Function Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568}.
Top Pathways Choline metabolism in cancer

OCT3 (C-14) - sc-18516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OCT3 (C-14): sc-18516. Western blot analysis of OCT3 expression in U-87 MG (A), JAR (B) and HUV-EC-C (C) whole cell lysates.

OCT3 (M-15) - sc-19818 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OCT3 (M-15): sc-19818. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing membrane staining of glandular cells.

OCT3 (P-16) - sc-18515 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OCT3 (P-16): sc-18515. Western blot analysis of OCT3 expression in U-87 MG (A) and HUV-EC-C (B) whole cell lysates.

OCT3 (N-12) - sc-19815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC22A3 antibody - ab183071 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC22A3 antibody (ab183071) at 1/600 dilution + Human liver cancer tissue lysate at 40 µgSecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutiondeveloped using the ECL technique

Anti-SLC22A3 antibody - ab126883 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-SLC22A3 antibody (ab126883) at 0.5 µg/ml + HEK293 lysate (35µg protein in RIPA buffer)

Anti-SLC22A3 antibody - ab189407 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling SLC22A3 with ab189407 at 20 µg/ml.

Anti-SLC22A3 antibody - ab74152 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC22A3 antibody (ab74152) at 1/500 dilutionLane 1 : COLO cell extractsLane 2 : HUVEC cell extractsLane 3 : HT-29 cell extractsLane 4 : HUVEC cell extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-SLC22A3 antibody [EPR6630] - ab124826 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6630
Overlay histogram showing JEG3 cells stained with ab124826 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab124826, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-SLC22A3 antibody [mAbcam75402] - ab75402 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam75402
Anti-SLC22A3 antibody [mAbcam75402] (ab75402) at 5 µg/ml + Prostate (Human) Whole Cell Lysate - liver cirrhosis (ab30307) at 20 µgSecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SLC22A3 antibody - N-terminal - ab191446 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC22A3 antibody - N-terminal (ab191446) at 0.5 µg/mlLane 1 : Rat liver tissue lysateLane 2 : 293T cell lysateLane 3 : A549 cell lysate

Anti-SLC22A3 / OCT3 Antibody - LS-C37857 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC22A3 / OCT3 Antibody (aa321-335) - LS-C154931 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SLC22A3 / OCT3 Antibody (Internal, clone 15B) - LS-C191735 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Clone 15B

Anti-SLC22A3 / OCT3 Antibody (aa13-26) - LS-C313280 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of SLC22A3 / OCT3 antibody. Lane 1: Rat Liver Tissue Lysate. Lane 2: 293T Cell Lysate. Lane 3: A549 Cell Lysate.

Anti-SLC22A3 / OCT3 Antibody (aa100-149) - LS-C135152 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC22A3 antibody LS-C135152 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-SLC22A3 / OCT3 Antibody (Gln306) - LS-C177484 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of OCT3 (Q306) pAb in extracts from HUVEC cells.

Anti-SLC22A3 / OCT3 Antibody (Internal, clone EPR6630) IHC-plus™ - LS-B8485 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6630
Anti-OCT3 / SLC22A3 antibody IHC of human colon epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8485 dilution 1:50-1:100.

Anti-SLC22A3 / OCT3 Antibody (aa275-324) IHC-plus™ - LS-B9260 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC22A3 / OCT3 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC22A3 / OCT3 Antibody (aa46-95) - LS-C40440 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC22A3 antibody LS-C40440 IHC of formalin-fixed, paraffin-embedded human Kidney. Positive label: Epithelial cells of renal tubule indicated with arrows. Antibody concentration 4-8 ug/ml. Magnification 400X.

SLC22A3 Antibody - NBP1-69368 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC22A3 Antibody - NBP1-83976 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SLC22A3 Antibody [NBP1-83976] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.

SLC22A3 Antibody - H00006581-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-SLC22A3 antibody produced in rabbit - HPA029750 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC22A3: <B>Cat. No. HPA029750</B>: Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.

Anti-SLC22A3 antibody produced in rabbit - SAB4502815 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC22A3: <B>Cat. No. SAB4502815</B>: Immunoblotting analysis of extracts from HuvEc/COLO/HT-29 cells, using Anti-SLC22A3 antibody. The lane on the left was treated with the Anti-SLC22A3 antibody. The lane on the right (negative control) was treated with both Anti-SLC22A3 antibody and the synthesized immunogen peptide.
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