| Gene Symbol |
SLC22A3
|
| Entrez Gene |
6581
|
| Alt Symbol |
EMT, EMTH, OCT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic cation transporter), member 3
|
| Other Description |
EMT organic cation transporter 3|extraneuronal monoamine transporter|organic cation transporter 3|solute carrier family 22 (extraneuronal monoamine transporter), member 3|solute carrier family 22 member 3
|
| Swissprots |
Q9UP02 Q5SYN6 O75751
|
| Accessions |
CAB96132 CAC39443 EAW47599 O75751 AF078749 AAD20977 AI810629 AJ001417 CAA04751 AK096980 AK125826 AK314590 BAG37164 BC070300 BC144280 BC156538 AAI56539 BC172500 AAI72500 BP320971 BX640965 XM_005267106 XP_005267163 XM_005267107 XP_005267164 XM_011536075 XP_011534377 XM_011536076 XP_011534378 XM_011536077 XP_011534379 XM_011536078 XP_011534380 XR_245546 NM_021977 NP_068812
|
| Function |
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568}.
|
| Top Pathways |
Choline metabolism in cancer
|