Gene Symbol | SLC22A3 |
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Entrez Gene | 6581 |
Alt Symbol | EMT, EMTH, OCT3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 22 (organic cation transporter), member 3 |
Other Description | EMT organic cation transporter 3|extraneuronal monoamine transporter|organic cation transporter 3|solute carrier family 22 (extraneuronal monoamine transporter), member 3|solute carrier family 22 member 3 |
Swissprots | Q9UP02 Q5SYN6 O75751 |
Accessions | CAB96132 CAC39443 EAW47599 O75751 AF078749 AAD20977 AI810629 AJ001417 CAA04751 AK096980 AK125826 AK314590 BAG37164 BC070300 BC144280 BC156538 AAI56539 BC172500 AAI72500 BP320971 BX640965 XM_005267106 XP_005267163 XM_005267107 XP_005267164 XM_011536075 XP_011534377 XM_011536076 XP_011534378 XM_011536077 XP_011534379 XM_011536078 XP_011534380 XR_245546 NM_021977 NP_068812 |
Function | Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568}. |
Top Pathways | Choline metabolism in cancer |
OCT3 CRISPR/Cas9 KO Plasmid (h) - sc-402959 from Santa Cruz Biotechnology
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OCT3 HDR Plasmid (h) - sc-402959-HDR from Santa Cruz Biotechnology
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OCT3 Double Nickase Plasmid (h) - sc-402959-NIC from Santa Cruz Biotechnology
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OCT3 Double Nickase Plasmid (h2) - sc-402959-NIC-2 from Santa Cruz Biotechnology
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OCT3 CRISPR Activation Plasmid (h) - sc-402959-ACT from Santa Cruz Biotechnology
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OCT3 CRISPR Activation Plasmid (h2) - sc-402959-ACT-2 from Santa Cruz Biotechnology
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OCT3 Lentiviral Activation Particles (h) - sc-402959-LAC from Santa Cruz Biotechnology
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OCT3 Lentiviral Activation Particles (h2) - sc-402959-LAC-2 from Santa Cruz Biotechnology
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OCT3 siRNA (h) - sc-42556 from Santa Cruz Biotechnology
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OCT3 shRNA Plasmid (h) - sc-42556-SH from Santa Cruz Biotechnology
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OCT3 shRNA (h) Lentiviral Particles - sc-42556-V from Santa Cruz Biotechnology
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SLC22A3 RNAi - H00006581-R01 from Novus Biologicals
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MISSION® esiRNA - EHU002291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19468 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19468 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14238 from Sigma-Aldrich
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SLC22A3 siRNA (Human) - CRH4469 from Cohesion Biosciences
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SLC22A3 - MBS8200527 from MyBioSource
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shRNA set against Human SLC22A3 (NM_021977.3) - SHH409184 from Creative biogene
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SLC22A3 shRNA Plasmid (Human) - CHH4469 from Cohesion Biosciences
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