Brca2

Gene Symbol	Brca2
Entrez Gene	12190
Alt Symbol	Fancd1, RAB163
Species	Mouse
Gene Type	protein-coding
Description	breast cancer 2
Other Description	breast cancer type 2 susceptibility protein homolog|fanconi anemia group D1 protein homolog
Swissprots	P97383 O35922 P97929 F8VPU5
Accessions	AAC53276 AAK57537 EDL05880 P97929 AK087379 AK132864 AK145017 AK148272 AK164598 AK165522 BAE38236 BC059904 AAH59904 BC172649 AAI72649 BU755677 U65594 AAC23702 U72947 AAB40720 U82270 AAB48306 U89652 AAB71377 XM_006504906 XP_006504969 XM_006504907 XP_006504970 XM_011241019 XP_011239321 XM_011241020 XP_011239322 XR_377265 NM_001081001 NP_001074470 NM_009765 NP_033895
Function	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) s
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity	Widely expressed. Highest expression in cerebellum, testis, ileum, appendix, epididymis, ovary and mammary gland. No expression in lung.
Top Pathways	Homologous recombination, Pancreatic cancer, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Breast Cancer Susceptibility Protein 2 (BRCA2), Mouse, ELISA Kit - SEB364Mu from ARP American Research Products Category ELISA Kit Prices $704.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

Breast cancer type 2 susceptibility protein homolog, Brca2, Mouse, ELISA Kit - E1364m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Mouse BRCA2 ELISA Kit - MB0467 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse Breast Cancer Susceptibility Protein 2 ELISA - E03B0460 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Breast Cancer Susceptibility Protein 2 (BRCA2) - SEB364Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse BRCA2 ELISA Kit - abx153731 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Breast Cancer Susceptibility Protein 2 (BRCA2), Mouse, ELISA Kit - DL-BRCA2-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse BRCA2 ELISA Kit - abx570794 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse BRCA-2 ELISA Kit - E046137 from Biobool Category ELISA Kit

Mouse Brca2 ELISA Kit - E046139 from Biobool Category ELISA Kit

Mouse BRCA2 ELISA Kit - EMB0467 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

BRCA2 ELISA Kit (Mouse) (OKCD02407) - OKCD02407 from Aviva Systems Biology Category ELISA Kit Prices $535.00 Sizes 10 ng Sensitivity 0.055 ng/mL Range 0.156-10 ng/mL

Breast Cancer Susceptibility Protein 2 (BRCA2), ELISA Kit - MBS452165 from MyBioSource Category ELISA Kit Prices $410.00, $540.00, $2,380.00, $4,620.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.063ng/mL Range 0.156-10ng/mL

Breast cancer type 2 susceptibility protein, ELISA Kit - MBS2886159 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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