Brca2

Gene Symbol Brca2
Entrez Gene 12190
Alt Symbol Fancd1, RAB163
Species Mouse
Gene Type protein-coding
Description breast cancer 2
Other Description breast cancer type 2 susceptibility protein homolog|fanconi anemia group D1 protein homolog
Swissprots P97383 O35922 P97929 F8VPU5
Accessions AAC53276 AAK57537 EDL05880 P97929 AK087379 AK132864 AK145017 AK148272 AK164598 AK165522 BAE38236 BC059904 AAH59904 BC172649 AAI72649 BU755677 U65594 AAC23702 U72947 AAB40720 U82270 AAB48306 U89652 AAB71377 XM_006504906 XP_006504969 XM_006504907 XP_006504970 XM_011241019 XP_011239321 XM_011241020 XP_011239322 XR_377265 NM_001081001 NP_001074470 NM_009765 NP_033895
Function Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) s
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Widely expressed. Highest expression in cerebellum, testis, ileum, appendix, epididymis, ovary and mammary gland. No expression in lung.
Top Pathways Homologous recombination, Pancreatic cancer, Fanconi anemia pathway

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Mu02 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Breast cancer type 2 susceptibility protein homolog(Brca2) ,partial - CSB-YP308755MO CSB-EP308755MO CSB-BP308755MO CSB-MP308755MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse BRCA2 Protein - BRCA2-2480M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

BRCA2 Recombinant Protein (OPCD01715) - OPCD01715 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Breast cancer type 2 susceptibility protein homolog (Brca2), partial, Recombinant Protein - MBS1059324 from MyBioSource

Category Protein
Prices $1,150.00, $1,150.00, $1,380.00, $1,380.00, $1,785.00, $1,785.00, $2,245.00, $2,245.00, $2,280.00, $3,525.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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