| Gene Symbol |
CYP2B6
|
| Entrez Gene |
1555
|
| Alt Symbol |
CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily B, polypeptide 6
|
| Other Description |
1,4-cineole 2-exo-monooxygenase|cytochrome P450 2B6|cytochrome P450 IIB1|cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
|
| Swissprots |
P20813 Q9UK46 Q2V565 B4DWP3
|
| Accessions |
AAD25924 AAF32444 ABB84469 AEA03268 AEA03269 AEA03270 AEA03271 AEA03272 AEA03273 AEA03274 AEA03275 AEA03276 AEA03277 EAW57015 P20813 AF182277 AAF13602 AK301620 BAG63105 BC067430 AAH67430 BC067431 AAH67431 M29874 AAA52144 X06399 X06400 X13494 XM_005258569 XP_005258626 XM_006723050 XP_006723113 XM_011526546 XP_011524848 XM_011526547 XP_011524849 XM_011526548 XP_011524850 XM_011526549 XP_011524851 XM_011526550 XP_011524852 NM_000767 NP_000758
|
| Function |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:20061448, ECO:0000269|PubMed:21875942, ECO:0000269|PubMed:22909231}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Expressed in liver, lung and heart right ventricle. {ECO:0000269|PubMed:10768437}.
|
| Top Pathways |
Arachidonic acid metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450
|