Gene Symbol | CYP2B6 |
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Entrez Gene | 1555 |
Alt Symbol | CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily B, polypeptide 6 |
Other Description | 1,4-cineole 2-exo-monooxygenase|cytochrome P450 2B6|cytochrome P450 IIB1|cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 |
Swissprots | P20813 Q9UK46 Q2V565 B4DWP3 |
Accessions | AAD25924 AAF32444 ABB84469 AEA03268 AEA03269 AEA03270 AEA03271 AEA03272 AEA03273 AEA03274 AEA03275 AEA03276 AEA03277 EAW57015 P20813 AF182277 AAF13602 AK301620 BAG63105 BC067430 AAH67430 BC067431 AAH67431 M29874 AAA52144 X06399 X06400 X13494 XM_005258569 XP_005258626 XM_006723050 XP_006723113 XM_011526546 XP_011524848 XM_011526547 XP_011524849 XM_011526548 XP_011524850 XM_011526549 XP_011524851 XM_011526550 XP_011524852 NM_000767 NP_000758 |
Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:20061448, ECO:0000269|PubMed:21875942, ECO:0000269|PubMed:22909231}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Expressed in liver, lung and heart right ventricle. {ECO:0000269|PubMed:10768437}. |
Top Pathways | Arachidonic acid metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |
Human Cytochrome P450 2B6 full length protein - ab114648 from Abcam
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CYP2B6 Antibody Blocking Peptide - LS-E747 from LifeSpan Bioscience
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CYP2B6 Antibody Blocking Peptide - LS-E15380 from LifeSpan Bioscience
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Recombinant Human Cytochrome P450 2B6 Protein - H00001555-P01 from Novus Biologicals
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CYP2B6-Antibody-Center-Blocking-peptide - BP11104c from Abgent, a WuXi AppTec company
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CYP2B6 Blocking Peptide - 33R-7624 from Fitzgerald
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P450 Blocking Peptide - 33R-9882 from Fitzgerald
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P450 Blocking Peptide - 33R-3924 from Fitzgerald
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Cytochrome P450 2B6 Blocking Peptide - abx062507 from Abbexa
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CYP2B6 - H00001555-P01-10 from Acris Antibodies
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CYP2B6 - H00001555-P01-25 from Acris Antibodies
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Recombinant Human CYP2B6 - CYP2B6-28193TH from Creative Biomart
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Recombinant Human CYP2B6 - CYP2B6-231H from Creative Biomart
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Recombinant Human CYP2B6 - CYP2B6-192H from Creative Biomart
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Recombinant Cytochrome P450 2B6 (CYP2B6) - RPD300Mu01 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 2B6 (CYP2B6) - RPD300Mu02 from Uscn Life Science Inc.
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Cytochrome P450 2B6 Blocking Peptide - CBP1313 from Cohesion Biosciences
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CYP2B6 (H271) Peptide - BS2403P from Bioworld Technology
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Recombinant Human Cytochrome P450 2B6(CYP2B6) - CSB-YP006414HU CSB-EP006414HU CSB-BP006414HU CSB-MP006414HU from Cusabio
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CYP2B6 - TP317236 from Acris Antibodies
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Cytochrome P450 2B6 Recombinant Protein Antigen - NBP2-13894PEP from Novus Biologicals
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CYP2B6 Peptide, Human - M34GP03955H from Creative Peptides
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Cytochrome P450 2B6 (CYP2B6), Recombinant Protein - MBS967684 from MyBioSource
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CYP2B6 peptide - orb217176 from Biorbyt
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