Gene Symbol | CYP2B6 |
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Entrez Gene | 1555 |
Alt Symbol | CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily B, polypeptide 6 |
Other Description | 1,4-cineole 2-exo-monooxygenase|cytochrome P450 2B6|cytochrome P450 IIB1|cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 |
Swissprots | P20813 Q9UK46 Q2V565 B4DWP3 |
Accessions | AAD25924 AAF32444 ABB84469 AEA03268 AEA03269 AEA03270 AEA03271 AEA03272 AEA03273 AEA03274 AEA03275 AEA03276 AEA03277 EAW57015 P20813 AF182277 AAF13602 AK301620 BAG63105 BC067430 AAH67430 BC067431 AAH67431 M29874 AAA52144 X06399 X06400 X13494 XM_005258569 XP_005258626 XM_006723050 XP_006723113 XM_011526546 XP_011524848 XM_011526547 XP_011524849 XM_011526548 XP_011524850 XM_011526549 XP_011524851 XM_011526550 XP_011524852 NM_000767 NP_000758 |
Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:20061448, ECO:0000269|PubMed:21875942, ECO:0000269|PubMed:22909231}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Expressed in liver, lung and heart right ventricle. {ECO:0000269|PubMed:10768437}. |
Top Pathways | Arachidonic acid metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |
CYP2B6 CRISPR/Cas9 KO Plasmid (h) - sc-417399 from Santa Cruz Biotechnology
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CYP2B6 HDR Plasmid (h) - sc-417399-HDR from Santa Cruz Biotechnology
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CYP2B6 Double Nickase Plasmid (h) - sc-417399-NIC from Santa Cruz Biotechnology
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CYP2B6 Double Nickase Plasmid (h2) - sc-417399-NIC-2 from Santa Cruz Biotechnology
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CYP2B6 CRISPR Activation Plasmid (h) - sc-417399-ACT from Santa Cruz Biotechnology
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CYP2B6 CRISPR Activation Plasmid (h2) - sc-417399-ACT-2 from Santa Cruz Biotechnology
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CYP2B6 Lentiviral Activation Particles (h) - sc-417399-LAC from Santa Cruz Biotechnology
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CYP2B6 Lentiviral Activation Particles (h2) - sc-417399-LAC-2 from Santa Cruz Biotechnology
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CYP2B6 siRNA (h) - sc-62181 from Santa Cruz Biotechnology
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CYP2B6 shRNA Plasmid (h) - sc-62181-SH from Santa Cruz Biotechnology
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CYP2B6 shRNA (h) Lentiviral Particles - sc-62181-V from Santa Cruz Biotechnology
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Cytochrome P450 2B6 RNAi - H00001555-R01 from Novus Biologicals
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MISSION® esiRNA - EHU006191 from Sigma-Aldrich
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MISSION® esiRNA - EHU107231 from Sigma-Aldrich
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MISSION® esiRNA - EHU147171 from Sigma-Aldrich
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CYP2B6 siRNA (Human) - CRH1097 from Cohesion Biosciences
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CYP2B6 - MBS8216775 from MyBioSource
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shRNA set against Human CYP2B6(NM_000767.4) - SHG216127 from Creative biogene
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CYP2B6 shRNA Plasmid (Human) - CHH1097 from Cohesion Biosciences
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CYP2B6 miRNA 3'UTR clone - MiUTR1H-02619 from Creative biogene
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