| Gene Symbol | PCSK6 |
|---|---|
| Entrez Gene | 5046 |
| Alt Symbol | PACE4, SPC4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proprotein convertase subtilisin/kexin type 6 |
| Other Description | paired basic amino acid cleaving enzyme 4|paired basic amino acid cleaving system 4|subtilisin-like proprotein convertase 4|subtilisin/kexin-like protease PACE4 |
| Swissprots | Q9UEJ2 Q9UEG7 Q9UEJ8 Q9Y4H0 P29122 Q9UEJ1 Q9UEJ7 Q9UEJ9 Q9Y4G9 Q15099 Q9Y4H1 Q15100 |
| Accessions | BAA21620 BAA21621 BAA21622 BAA21623 BAA21624 BAA21625 BAA21626 BAA21627 EAX02301 EAX02302 EAX02303 EAX02304 EAX02305 EAX02306 EAX02307 EAX02308 EAX02309 EAX02310 EAX02311 P29122 AB208955 BAD92192 AI478762 AL545278 AM491522 CAM33226 AW137040 BC043562 BU732171 BX428035 BX649058 D28513 BAA05871 D87993 BAA21791 D87994 BAA21792 D87995 BAA21793 DB143095 HY122769 HY205376 LN714797 CEK43043 M80482 AAA59998 NM_001291309 NP_001278238 NM_002570 NP_002561 NM_138319 NP_612192 NM_138322 NP_612195 NM_138323 NP_612196 NM_138324 NP_612197 NM_138325 NP_612198 NM_138320 NM_138321 |
| Function | Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. |
| Subcellular Location | Isoform PACE4B: Secreted. |
| Tissue Specificity | Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum. |