PCSK6

Gene Symbol PCSK6
Entrez Gene 5046
Alt Symbol PACE4, SPC4
Species Human
Gene Type protein-coding
Description proprotein convertase subtilisin/kexin type 6
Other Description paired basic amino acid cleaving enzyme 4|paired basic amino acid cleaving system 4|subtilisin-like proprotein convertase 4|subtilisin/kexin-like protease PACE4
Swissprots Q9UEJ2 Q9UEG7 Q9UEJ8 Q9Y4H0 P29122 Q9UEJ1 Q9UEJ7 Q9UEJ9 Q9Y4G9 Q15099 Q9Y4H1 Q15100
Accessions BAA21620 BAA21621 BAA21622 BAA21623 BAA21624 BAA21625 BAA21626 BAA21627 EAX02301 EAX02302 EAX02303 EAX02304 EAX02305 EAX02306 EAX02307 EAX02308 EAX02309 EAX02310 EAX02311 P29122 AB208955 BAD92192 AI478762 AL545278 AM491522 CAM33226 AW137040 BC043562 BU732171 BX428035 BX649058 D28513 BAA05871 D87993 BAA21791 D87994 BAA21792 D87995 BAA21793 DB143095 HY122769 HY205376 LN714797 CEK43043 M80482 AAA59998 NM_001291309 NP_001278238 NM_002570 NP_002561 NM_138319 NP_612192 NM_138322 NP_612195 NM_138323 NP_612196 NM_138324 NP_612197 NM_138325 NP_612198 NM_138320 NM_138321
Function Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.
Subcellular Location Isoform PACE4B: Secreted.
Tissue Specificity Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.

PACE4 (C-20) - sc-22899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PACE4 (C-20): sc-22899. Western blot analysis of PACE4 expression in HeLa (A) and K-562 (B) whole cell lysates and Hel.92.1.7 nuclear extract (C).

PACE4 (H-96) - sc-366495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PACE4 (H-96): sc-366495. Western blot analysis of PACE4 expression in human liver tissue extract.

PACE4 (K-18) - sc-22898 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PACE4 antibody - ab110144 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab110144, at 3.75 µg/ml, staining PACE4 in formalin fixed, paraffin embedded Human skeletal muscle by Immunohistochemistry.

Anti-PACE4 antibody - ab58226 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58226 PACE4 antibody at 1ug/ml.

Anti-PACE4 antibody - ab79721 from Abcam

Host Goat
Clonality Polyclonal

Anti-PACE4 antibody [EPR8320] - ab151562 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8320
ab151562 staining HeLa cells by ICC/IF. The cells were fixed with methanol. The cells were then stained with ab151562 at 1/200 in PBS for 1h at 22°C. An Alexa Fluro 488 goat anti-rabbit polyclonal antibody at 1/200 was used as the secondary antibody. ab151562 produces a focal staining pattern that is enriched within the cytoplasm.See Abreview

Anti-PACE4 antibody - Aminoterminal end - ab39877 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PACE4 antibody - Aminoterminal end (ab39877) at 1/1000 dilutionLane 1 : SF treated PK15 CMLane 2 : TPA treated PK15 CMLane 3 : IL1-beta treated PK15 CMLysates/proteins at 30 µl per lane.

Anti-PACE4 antibody - Carboxyterminal end - ab28542 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa659-688, Azide-free, HRP) - LS-C265806 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa659-688, Biotin) - LS-C265805 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa659-688, PE) - LS-C265808 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa658-688) - LS-C323867 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa218-267) - LS-C81995 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PACE4 / PCSK6 Antibody (clone 2D6) - LS-C197835 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D6
Detection limit for recombinant GST tagged PCSK6 is approximately 0.1 ng/ml as a capture antibody.

Anti-PACE4 / PCSK6 Antibody (Internal) IHC-plus™ - LS-A7857 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PACE4 antibody LS-A7857 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PACE4 / PCSK6 Antibody (Internal) IHC-plus™ - LS-A8407 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PACE4 antibody LS-A8407 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PACE4 / PCSK6 Antibody (aa659-688) - LS-C163450 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PCSK6 Antibody western blot of K562 cell line lysates (35 ug/lane). The PCSK6 antibody detected the PCSK6 protein (arrow).

Anti-PACE4 / PCSK6 Antibody (aa830-841) IHC-plus™ - LS-B4378 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-PACE4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4378 concentration 3.75 ug/ml.

Anti-PACE4 / PCSK6 Antibody (aa81-284) - LS-C17182 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (Internal) - LS-C144962 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa659-688, AP) - LS-C265803 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa301-350) - LS-C31343 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-PACE4 / PCSK6 Antibody (aa659-688, APC) - LS-C265802 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PACE4 / PCSK6 Antibody (aa659-688, FITC) - LS-C265804 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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