HELLS
| Gene Symbol | HELLS |
|---|---|
| Entrez Gene | 3070 |
| Alt Symbol | LSH, Nbla10143, PASG, SMARCA6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | helicase, lymphoid-specific |
| Other Description | SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6|SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6|lymphoid-specific helicase|proliferation-associated SNF2-like protein |
| Swissprots | Q6I7N7 Q76H80 Q76H78 Q76H79 Q3LID1 Q7Z5X2 Q7Z397 Q76H76 Q8N6P4 Q9H4P5 Q76H81 Q9NRZ9 B2RB41 Q76H77 |
| Accessions | EAW50026 EAW50027 EAW50028 EAW50029 EAW50030 EAW50031 EAW50032 EAW50033 EAW50034 EAW50035 EAW50036 EAW50037 EAW50038 Q9NRZ9 AB074174 BAE45737 AB102716 BAD10844 AB102717 BAD10845 AB102718 BAD10846 AB102719 BAD10847 AB102720 BAD10848 AB102721 BAD10849 AB102722 BAD10850 AB102723 BAD10851 AB113248 BAD24804 AB113249 BAD24805 AF155827 AAF82262 AK001201 BAA91550 AK022928 AK308331 AK314485 BAG37088 AY007108 AAG01987 BC015477 AAH15477 BC029381 AAH29381 BC030963 AAH30963 BC031004 AAH31004 BC068440 BC105606 AAI05607 BC111789 BC146308 AAI46309 BX538033 CAD97978 DC423372 EU831945 ACE87386 EU832040 ACE86702 NM_001289067 NP_001275996 NM_001289068 NP_001275997 NM_001289069 NP_001275998 NM_001289070 NP_001275999 NM_001289071 NP_001276000 NM_001289072 NP_001276001 NM_001289073 NP_001276002 NM_001289074 NP_001276003 NM_001289075 NP_001276004 NM_018063 NP_060533 |
| Function | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Subcellular Location | Nucleus {ECO:0000250}. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. {ECO:0000269|PubMed:10910076}. |
Human SMARCA6 full length protein - ab114875 from Abcam
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HELLS Antibody Blocking Peptide - LS-E13058 from LifeSpan Bioscience
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Recombinant Human SMARCA6 Protein - H00003070-P01 from Novus Biologicals
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HELLS-Antibody-Center-Blocking-peptide - BP12342c from Abgent, a WuXi AppTec company
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HELLS-Antibody-Center-Blocking-Peptide - BP5095c from Abgent, a WuXi AppTec company
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HELLS-Antibody-N-term-Blocking-peptide - BP5095a from Abgent, a WuXi AppTec company
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HELLS Blocking Peptide - 33R-7725 from Fitzgerald
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SMARCA6 / HELLS - H00003070-P01-10 from Acris Antibodies
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SMARCA6 / HELLS - H00003070-P01-25 from Acris Antibodies
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HELLS fusion protein - Ag2558 from Proteintech Group
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Recombinant Human HELLS - HELLS-31195TH from Creative Biomart
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Recombinant Human HELLS, GST-tagged - HELLS-13730H from Creative Biomart
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Recombinant Human Lymphoid-specific helicase(HELLS) ,partial - CSB-YP868307HU CSB-EP868307HU CSB-BP868307HU CSB-MP868307HU from Cusabio
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SMARCA6 / HELLS - TP312231 from Acris Antibodies
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SMARCA6 Recombinant Protein Antigen - NBP2-38986PEP from Novus Biologicals
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HELLS Peptide, Human - M34GP06928H from Creative Peptides
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Lymphoid-specific helicase (HELLS), partial, Recombinant Protein - MBS1410625 from MyBioSource
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