HELLS

Gene Symbol	HELLS
Entrez Gene	3070
Alt Symbol	LSH, Nbla10143, PASG, SMARCA6
Species	Human
Gene Type	protein-coding
Description	helicase, lymphoid-specific
Other Description	SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6|SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6|lymphoid-specific helicase|proliferation-associated SNF2-like protein
Swissprots	Q6I7N7 Q76H80 Q76H78 Q76H79 Q3LID1 Q7Z5X2 Q7Z397 Q76H76 Q8N6P4 Q9H4P5 Q76H81 Q9NRZ9 B2RB41 Q76H77
Accessions	EAW50026 EAW50027 EAW50028 EAW50029 EAW50030 EAW50031 EAW50032 EAW50033 EAW50034 EAW50035 EAW50036 EAW50037 EAW50038 Q9NRZ9 AB074174 BAE45737 AB102716 BAD10844 AB102717 BAD10845 AB102718 BAD10846 AB102719 BAD10847 AB102720 BAD10848 AB102721 BAD10849 AB102722 BAD10850 AB102723 BAD10851 AB113248 BAD24804 AB113249 BAD24805 AF155827 AAF82262 AK001201 BAA91550 AK022928 AK308331 AK314485 BAG37088 AY007108 AAG01987 BC015477 AAH15477 BC029381 AAH29381 BC030963 AAH30963 BC031004 AAH31004 BC068440 BC105606 AAI05607 BC111789 BC146308 AAI46309 BX538033 CAD97978 DC423372 EU831945 ACE87386 EU832040 ACE86702 NM_001289067 NP_001275996 NM_001289068 NP_001275997 NM_001289069 NP_001275998 NM_001289070 NP_001275999 NM_001289071 NP_001276000 NM_001289072 NP_001276001 NM_001289073 NP_001276002 NM_001289074 NP_001276003 NM_001289075 NP_001276004 NM_018063 NP_060533
Function	Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}.
Subcellular Location	Nucleus {ECO:0000250}. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}.
Tissue Specificity	Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. {ECO:0000269|PubMed:10910076}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® HELLS siRNA I - 11822 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® HELLS siRNA II - 11823 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Lsh CRISPR/Cas9 KO Plasmid (h) - sc-402466 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh HDR Plasmid (h) - sc-402466-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh Double Nickase Plasmid (h) - sc-402466-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh Double Nickase Plasmid (h2) - sc-402466-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh CRISPR Activation Plasmid (h) - sc-402466-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh CRISPR Activation Plasmid (h2) - sc-402466-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh Lentiviral Activation Particles (h) - sc-402466-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh Lentiviral Activation Particles (h2) - sc-402466-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Lsh siRNA (h) - sc-38033 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Lsh shRNA Plasmid (h) - sc-38033-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Lsh shRNA (h) Lentiviral Particles - sc-38033-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMARCA6 RNAi - H00003070-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU075091 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9967 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9967 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04154 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04154

HELLS siRNA (Human) - CRH2091 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HELLS - MBS8208750 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HELLS(NM_018063.3) - SHH118055 from Creative biogene Category siRNA Species Reactivities Human

Human HELLS siRNA - orb262593 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HELLS shRNA Plasmid (Human) - CHH2091 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HELLS miRNA 3'UTR clone - MiUTR1H-04454 from Creative biogene Species Reactivities Human

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