HELLS

Gene Symbol HELLS
Entrez Gene 3070
Alt Symbol LSH, Nbla10143, PASG, SMARCA6
Species Human
Gene Type protein-coding
Description helicase, lymphoid-specific
Other Description SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6|SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6|lymphoid-specific helicase|proliferation-associated SNF2-like protein
Swissprots Q6I7N7 Q76H80 Q76H78 Q76H79 Q3LID1 Q7Z5X2 Q7Z397 Q76H76 Q8N6P4 Q9H4P5 Q76H81 Q9NRZ9 B2RB41 Q76H77
Accessions EAW50026 EAW50027 EAW50028 EAW50029 EAW50030 EAW50031 EAW50032 EAW50033 EAW50034 EAW50035 EAW50036 EAW50037 EAW50038 Q9NRZ9 AB074174 BAE45737 AB102716 BAD10844 AB102717 BAD10845 AB102718 BAD10846 AB102719 BAD10847 AB102720 BAD10848 AB102721 BAD10849 AB102722 BAD10850 AB102723 BAD10851 AB113248 BAD24804 AB113249 BAD24805 AF155827 AAF82262 AK001201 BAA91550 AK022928 AK308331 AK314485 BAG37088 AY007108 AAG01987 BC015477 AAH15477 BC029381 AAH29381 BC030963 AAH30963 BC031004 AAH31004 BC068440 BC105606 AAI05607 BC111789 BC146308 AAI46309 BX538033 CAD97978 DC423372 EU831945 ACE87386 EU832040 ACE86702 NM_001289067 NP_001275996 NM_001289068 NP_001275997 NM_001289069 NP_001275998 NM_001289070 NP_001275999 NM_001289071 NP_001276000 NM_001289072 NP_001276001 NM_001289073 NP_001276002 NM_001289074 NP_001276003 NM_001289075 NP_001276004 NM_018063 NP_060533
Function Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}.
Subcellular Location Nucleus {ECO:0000250}. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}.
Tissue Specificity Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. {ECO:0000269|PubMed:10910076}.

HELLS Antibody - 7998 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using HELLS Antibody.

Lsh (C-1) - sc-365815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lsh (C-1): sc-365815. Western blot analysis of Lsh expression in CCRF-CEM (A) and JM1 (B) whole cell lysates.

Lsh (22) - sc-136459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lsh (22): sc-136459. Western blot analysis of Lsh expression in Jurkat whole cell lysate.

Lsh (C-8) - sc-365814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lsh (C-8): sc-365814. Western blot analysis of Lsh expression in CCRF-CEM (A) and JM1 (B) whole cell lysates.

Lsh (H-240) - sc-28202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Lsh (H-240): sc-28202. Western blot analysis of Lsh expression in CCRF-CEM whole cell lysate.

Lsh (M-15) - sc-11844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lsh (M-15): sc-11844. Western blot analysis of Lsh expression in F9 whole cell lysate.

Lsh (H-4) - sc-46665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lsh (H-4): sc-46665. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of follicle cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Lsh (N-16) - sc-11841 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lsh (N-16): sc-11841. Western blot analysis of Lsh expression in CCRF-CEM nuclear extract.

Anti-SMARCA6 antibody - ab3851 from Abcam

Prices $380.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Detection of Human HELLS by Western Blot of Immunoprecipitate using Affinity Purified Rabbit anti-HELLS (ab3851).Sample: Nuclear Extract (1mg) from HeLa cellsAntibody: Affinity purified Rabbit anti-HELLS (ab3851)IP - 2µg. WB - 0.5µg/mlDetection: ECL, 30 seconds 

Anti-SMARCA6 antibody - ab192325 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA6 antibody - ab55095 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SMARCA6 antibody - N-terminal - ab135096 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-SMARCA6 antibody - N-terminal (ab135096) at 1/1000 dilution + HeLa total cell extract

Anti-HELLS Antibody - LS-C67390 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HELLS Antibody - LS-C190082 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HELLS / LSH Antibody (aa1-349, clone 10D68, Azide-free) - LS-C183679 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10D68

Anti-HELLS Antibody - LS-C310591 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HELLS Antibody - LS-C308210 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HELLS Antibody - LS-C341896 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HELLS Antibody (aa756-805) - LS-C110163 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HELLS antibody LS-C110163 Western blot of HepG2 cell lysate.

Anti-HELLS Antibody (aa550-600) - LS-C287142 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human HELLS by Western Blot of Immunoprecipitate. Sample: Nuclear extract (1 mg) from HeLa cells. Antibody: Affinity purified rabbit anti-HELLS used at 2 ug/mg lysate for IP and 0.5 ug/ml for Western Blot. Detection: Chemiluminescence with 30 second exposure.

Anti-HELLS Antibody (clone 1D10) - LS-C197403 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D10
Western Blot analysis of HELLS expression in transfected 293T cell line by HELLS monoclonal antibody (M01), clone 1D10.Lane 1: HELLS transfected lysate (Predicted MW: 97.074 KDa).Lane 2: Non-transfected lysate.

Anti-HELLS Antibody - LS-C334324 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using KDM3A antibody. Blue: DAPI for nuclear staining.

SMARCA6 Antibody - NB100-278 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMARCA6 Antibody - NBP1-57145 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMARCA6 Antibody [NBP1-57145] - MCF7, Antibody Dilution: 1.0 ug/ml HELLS is supported by BioGPS gene expression data to be expressed in MCF7.

SMARCA6 Antibody - NBP2-38986 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMARCA6 Antibody [NBP2-38986] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG
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