GPRC5B
| Gene Symbol | GPRC5B |
|---|---|
| Entrez Gene | 51704 |
| Alt Symbol | RAIG-2, RAIG2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | G protein-coupled receptor, class C, group 5, member B |
| Other Description | G protein-coupled receptor, family C, group 1, member B|G-protein coupled receptor family C group 5 member B|retinoic acid responsive gene protein|retinoic acid-induced gene 2 protein |
| Swissprots | Q9NZH0 D2DFB0 Q8NBZ8 O75205 |
| Accessions | AAC27544 EAW50302 EAW50303 EAW50304 EAW50305 Q9NZH0 AF181862 AAF05331 AF202640 AAF67321 AJ276101 CAC00632 AK075119 BAC11414 AK294680 BAH11846 AK295204 BAH12012 AK296754 BAH12426 AK302838 BAH13817 AK315989 BAH14360 AL137684 BC034467 AAH34467 BI462652 DA141861 DC344063 DQ890851 ABM81777 DQ894006 ABM84932 FJ529380 ACU30030 XM_006721051 XP_006721114 XM_006721052 XP_006721115 NM_001304771 NP_001291700 NM_016235 NP_057319 |
| Function | Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10945465}; Multi-pass membrane protein {ECO:0000269|PubMed:10945465}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10945465}; Multi- pass membrane protein {ECO:0000269|PubMed:10945465}. Note=Localized in the plasma membrane and perinuclear vesicles. |
| Tissue Specificity | Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach. {ECO:0000269|PubMed:10783259, ECO:0000269|PubMed:10945465}. |
GPRC5B CRISPR/Cas9 KO Plasmid (h) - sc-409271 from Santa Cruz Biotechnology
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GPRC5B HDR Plasmid (h) - sc-409271-HDR from Santa Cruz Biotechnology
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GPRC5B Double Nickase Plasmid (h) - sc-409271-NIC from Santa Cruz Biotechnology
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GPRC5B Double Nickase Plasmid (h2) - sc-409271-NIC-2 from Santa Cruz Biotechnology
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GPRC5B CRISPR Activation Plasmid (h) - sc-409271-ACT from Santa Cruz Biotechnology
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GPRC5B CRISPR Activation Plasmid (h2) - sc-409271-ACT-2 from Santa Cruz Biotechnology
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GPRC5B Lentiviral Activation Particles (h) - sc-409271-LAC from Santa Cruz Biotechnology
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GPRC5B Lentiviral Activation Particles (h2) - sc-409271-LAC-2 from Santa Cruz Biotechnology
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GPRC5B siRNA (h) - sc-62409 from Santa Cruz Biotechnology
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GPRC5B shRNA Plasmid (h) - sc-62409-SH from Santa Cruz Biotechnology
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GPRC5B shRNA (h) Lentiviral Particles - sc-62409-V from Santa Cruz Biotechnology
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GPRC5B RNAi - H00051704-R02 from Novus Biologicals
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MISSION® esiRNA - EHU132241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9631 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09521 from Sigma-Aldrich
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GPRC5B siRNA (Human) - CRH9910 from Cohesion Biosciences
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GPRC5B - MBS828241 from MyBioSource
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shRNA set against Human GPRC5B (NM_016235.1) - SHH307198 from Creative biogene
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Human GPRC5B siRNA - orb270412 from Biorbyt
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GPRC5B shRNA Plasmid (Human) - CHH9910 from Cohesion Biosciences
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GPRC5B miRNA 3'UTR clone - MiUTR1H-04232 from Creative biogene
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