| Gene Symbol |
NUF2
|
| Entrez Gene |
83540
|
| Alt Symbol |
CDCA1, CT106, NUF2R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NUF2, NDC80 kinetochore complex component
|
| Other Description |
NUF2, NDC80 kinetochore complex component, homolog|cancer/testis antigen 106|cell division cycle associated 1|cell division cycle-associated protein 1|hNuf2|hNuf2R|hsNuf2|kinetochore protein Nuf2
|
| Swissprots |
Q96HJ4 Q9BZD4 Q96Q78 Q8WU69
|
| Accessions |
EAW90735 EAW90736 EAW90737 Q9BZD4 AB050577 BAB59141 AB050578 BAB59142 AF326731 AAK01426 AK093348 BAC04140 BC008489 AAH08489 BC021171 AAH21171 BI545465 DQ893170 ABM84096 DQ896469 ABM87468 XM_011510036 XP_011508338 NM_031423 NP_113611 NM_145697 NP_663735
|
| Function |
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
|