| Gene Symbol | NUF2 |
|---|---|
| Entrez Gene | 83540 |
| Alt Symbol | CDCA1, CT106, NUF2R |
| Species | Human |
| Gene Type | protein-coding |
| Description | NUF2, NDC80 kinetochore complex component |
| Other Description | NUF2, NDC80 kinetochore complex component, homolog|cancer/testis antigen 106|cell division cycle associated 1|cell division cycle-associated protein 1|hNuf2|hNuf2R|hsNuf2|kinetochore protein Nuf2 |
| Swissprots | Q96HJ4 Q9BZD4 Q96Q78 Q8WU69 |
| Accessions | EAW90735 EAW90736 EAW90737 Q9BZD4 AB050577 BAB59141 AB050578 BAB59142 AF326731 AAK01426 AK093348 BAC04140 BC008489 AAH08489 BC021171 AAH21171 BI545465 DQ893170 ABM84096 DQ896469 ABM87468 XM_011510036 XP_011508338 NM_031423 NP_113611 NM_145697 NP_663735 |
| Function | Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814}. |
| Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization. |
CdcA1 CRISPR/Cas9 KO Plasmid (h) - sc-408292 from Santa Cruz Biotechnology
|
||||||||
CdcA1 HDR Plasmid (h) - sc-408292-HDR from Santa Cruz Biotechnology
|
||||||||
CdcA1 Double Nickase Plasmid (h) - sc-408292-NIC from Santa Cruz Biotechnology
|
||||||||
CdcA1 Double Nickase Plasmid (h2) - sc-408292-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CdcA1 CRISPR Activation Plasmid (h) - sc-408292-ACT from Santa Cruz Biotechnology
|
||||||||
CdcA1 CRISPR Activation Plasmid (h2) - sc-408292-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CdcA1 Lentiviral Activation Particles (h) - sc-408292-LAC from Santa Cruz Biotechnology
|
||||||||
CdcA1 Lentiviral Activation Particles (h2) - sc-408292-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CdcA1 siRNA (h) - sc-72839 from Santa Cruz Biotechnology
|
||||||||
CdcA1 shRNA Plasmid (h) - sc-72839-SH from Santa Cruz Biotechnology
|
||||||||
CdcA1 shRNA (h) Lentiviral Particles - sc-72839-V from Santa Cruz Biotechnology
|
||||||||
CdcA1 siRNA (h) - sc-78770 from Santa Cruz Biotechnology
|
||||||||
CdcA1 shRNA Plasmid (h) - sc-78770-SH from Santa Cruz Biotechnology
|
||||||||
CdcA1 shRNA (h) Lentiviral Particles - sc-78770-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU055571 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15611 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15611 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR02131 from Sigma-Aldrich
|
||||||||
NUF2 siRNA (Human) - CRJ3121 from Cohesion Biosciences
|
||||||||
shRNA set against Human NUF2 (NM_031423.3) - SHH356272 from Creative biogene
|
||||||||
shRNA set against Human NUF2(NM_031423.3) - SHR003346 from Creative biogene
|
||||||||
Human NUF2 siRNA - orb273622 from Biorbyt
|
||||||||
NUF2 shRNA Plasmid (Human) - CHJ3121 from Cohesion Biosciences
|
||||||||
NUF2 miRNA 3'UTR clone - MiUTR1H-06974 from Creative biogene
|
||||||||
NUF2 miRNA 3'UTR clone - MiUTR4H-TG06181 from Creative biogene
|