| Gene Symbol |
AICDA
|
| Entrez Gene |
57379
|
| Alt Symbol |
AID, ARP2, CDA2, HEL-S-284, HIGM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activation-induced cytidine deaminase
|
| Other Description |
cytidine aminohydrolase|epididymis secretory protein Li 284|integrated into Burkitt's lymphoma cell line Ramos|single-stranded DNA cytosine deaminase
|
| Swissprots |
Q8NFC1 Q9GZX7 Q6QJ81
|
| Accessions |
BAB12720 BAC66114 CAI75242 CBX87165 EAW88615 Q9GZX7 AB040431 BAB12721 AF529815 AAM95402 AF529816 AAM95403 AF529817 AAM95404 AF529818 AAM95405 AF529819 AAM95406 AF529820 AAM95407 AF529821 AAM95408 AF529822 AAM95409 AF529823 AAM95410 AF529824 AAM95411 AF529825 AAM95412 AF529826 AAM95413 AF529827 AAM95414 AJ577811 CAE12261 AM393608 CAL38484 AY534975 AAS90604 AY536516 AAS92920 AY536517 AAS92921 AY541058 AAS98257 AY748364 AAU95780 BC006296 AAH06296 BT007402 AAP36066 BX402063 DQ431660 ABD92700 DQ892989 ABM83915 DQ896237 ABM87236 EU794587 ACJ13641 XM_011520772 XP_011519074 XM_011520773 XP_011519075 NM_020661 NP_065712
|
| Function |
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.
|
| Tissue Specificity |
Strongly expressed in lymph nodes and tonsils. {ECO:0000269|PubMed:23166356}.
|
| Top Pathways |
Primary immunodeficiency, Intestinal immune network for IgA production
|
![Western Blot: AICDA Overexpression Lysate (Adult Normal) [NBL1-07406] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AICDA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/721_AICDA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07406-img0002.jpg)