Gene Symbol | AICDA |
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Entrez Gene | 57379 |
Alt Symbol | AID, ARP2, CDA2, HEL-S-284, HIGM2 |
Species | Human |
Gene Type | protein-coding |
Description | activation-induced cytidine deaminase |
Other Description | cytidine aminohydrolase|epididymis secretory protein Li 284|integrated into Burkitt's lymphoma cell line Ramos|single-stranded DNA cytosine deaminase |
Swissprots | Q8NFC1 Q9GZX7 Q6QJ81 |
Accessions | BAB12720 BAC66114 CAI75242 CBX87165 EAW88615 Q9GZX7 AB040431 BAB12721 AF529815 AAM95402 AF529816 AAM95403 AF529817 AAM95404 AF529818 AAM95405 AF529819 AAM95406 AF529820 AAM95407 AF529821 AAM95408 AF529822 AAM95409 AF529823 AAM95410 AF529824 AAM95411 AF529825 AAM95412 AF529826 AAM95413 AF529827 AAM95414 AJ577811 CAE12261 AM393608 CAL38484 AY534975 AAS90604 AY536516 AAS92920 AY536517 AAS92921 AY541058 AAS98257 AY748364 AAU95780 BC006296 AAH06296 BT007402 AAP36066 BX402063 DQ431660 ABD92700 DQ892989 ABM83915 DQ896237 ABM87236 EU794587 ACJ13641 XM_011520772 XP_011519074 XM_011520773 XP_011519075 NM_020661 NP_065712 |
Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm. |
Tissue Specificity | Strongly expressed in lymph nodes and tonsils. {ECO:0000269|PubMed:23166356}. |
Top Pathways | Primary immunodeficiency, Intestinal immune network for IgA production |
AID CRISPR/Cas9 KO Plasmid (h) - sc-401542 from Santa Cruz Biotechnology
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AID HDR Plasmid (h) - sc-401542-HDR from Santa Cruz Biotechnology
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AID Double Nickase Plasmid (h) - sc-401542-NIC from Santa Cruz Biotechnology
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AID Double Nickase Plasmid (h2) - sc-401542-NIC-2 from Santa Cruz Biotechnology
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AID CRISPR Activation Plasmid (h) - sc-401542-ACT from Santa Cruz Biotechnology
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AID CRISPR Activation Plasmid (h2) - sc-401542-ACT-2 from Santa Cruz Biotechnology
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AID Lentiviral Activation Particles (h) - sc-401542-LAC from Santa Cruz Biotechnology
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AID Lentiviral Activation Particles (h2) - sc-401542-LAC-2 from Santa Cruz Biotechnology
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AID siRNA (h) - sc-42729 from Santa Cruz Biotechnology
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AID shRNA Plasmid (h) - sc-42729-SH from Santa Cruz Biotechnology
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AID shRNA (h) Lentiviral Particles - sc-42729-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2978 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2978 from Sigma-Aldrich
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AICDA siRNA (Human) - CRJ1424 from Cohesion Biosciences
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AICDA RNAi - H00057379-R01 from Novus Biologicals
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AICDA - MBS8236172 from MyBioSource
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shRNA set against Human AIC (NM_020661.2) - SHH233862 from Creative biogene
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Human AICDA siRNA - orb271925 from Biorbyt
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AICDA shRNA Plasmid (Human) - CHJ1424 from Cohesion Biosciences
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AICDA miRNA 3'UTR clone - MiUTR4H-TG00228 from Creative biogene
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