AICDA

Gene Symbol	AICDA
Entrez Gene	57379
Alt Symbol	AID, ARP2, CDA2, HEL-S-284, HIGM2
Species	Human
Gene Type	protein-coding
Description	activation-induced cytidine deaminase
Other Description	cytidine aminohydrolase|epididymis secretory protein Li 284|integrated into Burkitt's lymphoma cell line Ramos|single-stranded DNA cytosine deaminase
Swissprots	Q8NFC1 Q9GZX7 Q6QJ81
Accessions	BAB12720 BAC66114 CAI75242 CBX87165 EAW88615 Q9GZX7 AB040431 BAB12721 AF529815 AAM95402 AF529816 AAM95403 AF529817 AAM95404 AF529818 AAM95405 AF529819 AAM95406 AF529820 AAM95407 AF529821 AAM95408 AF529822 AAM95409 AF529823 AAM95410 AF529824 AAM95411 AF529825 AAM95412 AF529826 AAM95413 AF529827 AAM95414 AJ577811 CAE12261 AM393608 CAL38484 AY534975 AAS90604 AY536516 AAS92920 AY536517 AAS92921 AY541058 AAS98257 AY748364 AAU95780 BC006296 AAH06296 BT007402 AAP36066 BX402063 DQ431660 ABD92700 DQ892989 ABM83915 DQ896237 ABM87236 EU794587 ACJ13641 XM_011520772 XP_011519074 XM_011520773 XP_011519075 NM_020661 NP_065712
Function	Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874}.
Subcellular Location	Nucleus. Cytoplasm. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.
Tissue Specificity	Strongly expressed in lymph nodes and tonsils. {ECO:0000269|PubMed:23166356}.
Top Pathways	Primary immunodeficiency, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AICDA full length protein - ab139251 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human AICDA peptide - ab13718 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Source CHO

AICDA / AID Antibody Blocking Peptide - LS-E30009 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AICDA / AID Antibody Blocking Peptide - LS-E26667 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AICDA Protein - H00057379-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

AICDA Blocking Peptide - NBP1-77235PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human AICDA Protein - NBP2-22671 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

AICDA blocking peptide - GTX88708-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human AICDA protein - orb167866 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

AICDA Immunizing peptide - orb50465 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

AICDA protein (His tag) - 30R-2959 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

AID Blocking Peptide - abx161011 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Rabbit

AID Blocking Peptide - abx161012 from Abbexa Category Peptide Species Human, Mouse, Rat

AICDA Peptide - AC21-1504-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AICDA / AID (1-198, His-tag) - AR50719PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

AICDA / AID (1-198, His-tag) - AR50719PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

AICDA / AID - H00057379-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AICDA / AID - H00057379-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AICDA / AID Control Peptide - AP30028CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

AICDA, 1-198aa, Human, His tag, E.coli - 01-P1895 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

AID Peptide - 3091P from ProSci Category Peptide Species Human

AID Peptide - 45-218P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

AID fusion protein - Ag8236 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

AID fusion protein - ag8136 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AICDA Human - ENPS-658 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

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