ATF4

Gene Symbol	ATF4
Entrez Gene	468
Alt Symbol	CREB-2, CREB2, TAXREB67, TXREB
Species	Human
Gene Type	protein-coding
Description	activating transcription factor 4
Other Description	DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-responsive enhancer element B67|tax-responsive enhancer element-binding protein 67
Swissprots	Q9UH31 P18848
Accessions	EAW60341 EAW60342 P18848 AK057751 AK296028 BAG58796 BC008090 AAH08090 BC011994 AAH11994 BC016855 AAH16855 BC022088 AAH22088 BC024775 AAH24775 BC044895 AAH44895 BC073754 AAH73754 BC073990 AAH73990 CR450353 CAG29349 CR456384 CAG30270 CU012942 CAK54373 CU013230 CAK54672 D90209 BAA14234 DQ891758 ABM82684 DQ894942 ABM85868 M86842 AAA52071 NM_001675 NP_001666 NM_182810 NP_877962
Function	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.
Top Pathways	MAPK signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Adrenergic signaling in cardiomyocytes, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Activating Transcription Factor 4 Gene - orb91619 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-ATF4-cDNA-Clone - DC04369 from Abgent, a WuXi AppTec company Prices $473.85 Sizes 10 µg Species Human Accession BC008090

ATF4 - MBS1278474 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016855

ATF4 - MBS1277988 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC008090

Human ATF4 Gene cDNA clone plasmid - HG11124-M from Sino Biological Species Human

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-tagged - HG11124-CY from Sino Biological Species Human Accession NM_182810.1

Human ATF4 ORF mammalian expression plasmid, Flag tag - HG11124-M-F from Sino Biological Species Human Accession NM_182810.1

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11124-M-N from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid - HG11124-UT from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG11124-ACG from Sino Biological Species Human Accession NM_182810.1

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG11124-NY from Sino Biological Species Human Accession NM_182810.1

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG11124-NH from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid, N-Flag tag - HG11124-NF from Sino Biological Species Human Accession NM_182810.1

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged - HG11124-NM from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid, C-Flag tag - HG11124-CF from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid, N-GFPSpark tag - HG11124-ANG from Sino Biological Species Human Accession NM_182810.1

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG11124-CH from Sino Biological Species Human Accession NM_182810.1

Human ATF4 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-tagged - HG11124-CM from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid, C-OFPSpark tag - HG11124-ACR from Sino Biological Species Human Accession NM_182810.1

Human ATF4 natural ORF mammalian expression plasmid, N-OFPSpark tag - HG11124-ANR from Sino Biological Species Human Accession NM_182810.1

ATF4 - CL01179H01 from Elabscience Species Human Accession NM_001675.2

ATF4 - CL01179H02 from Elabscience Species Human Accession NM_182810.1

Human ATF4 ORF clone(NM_182810.1) - CDCL182772 from Creative biogene Species Human

Human ATF4 ORF Clone(NM_001675.2) - CDCR280903 from Creative biogene Species Human

Human ATF4 ORF Clone (BC008090) - CDCS410370 from Creative biogene Species Human Accession P18848

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