ATF4

Gene Symbol	ATF4
Entrez Gene	468
Alt Symbol	CREB-2, CREB2, TAXREB67, TXREB
Species	Human
Gene Type	protein-coding
Description	activating transcription factor 4
Other Description	DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-responsive enhancer element B67|tax-responsive enhancer element-binding protein 67
Swissprots	Q9UH31 P18848
Accessions	EAW60341 EAW60342 P18848 AK057751 AK296028 BAG58796 BC008090 AAH08090 BC011994 AAH11994 BC016855 AAH16855 BC022088 AAH22088 BC024775 AAH24775 BC044895 AAH44895 BC073754 AAH73754 BC073990 AAH73990 CR450353 CAG29349 CR456384 CAG30270 CU012942 CAK54373 CU013230 CAK54672 D90209 BAA14234 DQ891758 ABM82684 DQ894942 ABM85868 M86842 AAA52071 NM_001675 NP_001666 NM_182810 NP_877962
Function	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.
Top Pathways	MAPK signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Adrenergic signaling in cardiomyocytes, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATF-4 full length protein - ab109946 from Abcam Category Protein Prices $402.00, $1,210.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Human ATF-4 peptide - ab24034 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human ATF-4 peptide - ab22854 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human ATF-4 protein fragment - ab91898 from Abcam Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

ATF4 Antibody Blocking Peptide - LS-E1517 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATF4 Antibody Blocking Peptide - LS-E25271 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATF4 Antibody Blocking Peptide - LS-E13654 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATF4 Antibody Blocking Peptide - LS-E13655 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATF4 Antibody Blocking Peptide - LS-E13280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATF4 Antibody Blocking Peptide - LS-E13279 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATF4 Recombinant Protein - H00000468-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ATF4 Recombinant Protein - H00000468-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ATF4 Protein - NBP1-72383 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

ATF4 Peptide - P1911 from Novus Biologicals Category Peptide Species Human

ATF4-Antibody-S245-Blocking-Peptide - BP6287a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATF4-Antibody-Center-Blocking-peptide - BP12242c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATF4 blocking peptide - GTX89973-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Rat

Human ATF4 protein - orb167940 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

Goat anti ATF4 antibody Immunizing peptide - orb17606 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ATF4 (phospho-Ser245) Blocking Peptide - abx062033 from Abbexa Category Peptide Species Human, Mouse, Rat

ATF4 Blocking Peptide - abx062276 from Abbexa Category Peptide Species Human, Mouse, Rat

Human ATF4 Protein - abx065127 from Abbexa Category Protein Source E.coli Species Human

ATF4 Peptide - AC21-0099-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ATF4 (1-351, His-Cam-tag) - AR39078PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

ATF4 (1-351, His-Cam-tag) - AR39078PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

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