| Gene Symbol |
PRMT2
|
| Entrez Gene |
3275
|
| Alt Symbol |
HRMT1L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein arginine methyltransferase 2
|
| Other Description |
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1|HMT1 hnRNP methyltransferase-like 1|PRMT2 alpha|PRMT2 beta|PRMT2 gamma|histone-arginine N-methyltransferase PRMT2|protein arginine N-methyltransferase 2
|
| Swissprots |
Q6FHF0 B7U631 P78350 Q9BW15 P55345 Q99781 Q5U7D4 Q9UMC2 B7U632 Q498Y5 B7U630
|
| Accessions |
CBX51391 EAX09258 EAX09259 EAX09260 EAX09261 EAX09262 EAX09263 EAX09264 EAX09265 P55345 AF059319 AAG43116 AI801643 AK055950 AK095641 AK123352 AK123650 BAG53931 AK124494 AK223157 BAD96877 AK312573 AL109794 CAB52454 AL833586 AY786414 AAV48568 BC000727 AAH00727 BC038765 AAH38765 BC100026 AAI00027 BF683143 BM976817 BQ267811 BQ421001 BY799824 CA427786 CB045875 CB529922 CN293838 CR541804 CAG46603 DA169949 DA517312 DA708321 DB160043 DQ892126 ABM83052 DQ895319 ABM86245 FJ436410 ACJ66866 FJ436411 ACJ66867 FJ436412 ACJ66868 U79286 AAB50221 U80213 AAB48437 X99209 CAA67599 XM_005261111 XP_005261168 XM_006723998 XP_006724061 XM_006723999 XP_006724062 XM_006724000 XP_006724063 NM_001242864 NP_001229793 NM_001242865 NP_001229794 NM_001242866 NP_001229795 NM_001286676 NP_001273605 NM_001286677 NP_001273606 NM_001286678 NP_001273607 NM_001535 NP_001526 NM_206962 NP_996845
|
| Function |
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. {ECO:0000269|PubMed:12039952, ECO:0000269|PubMed:16648481, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19405910}.
|
| Subcellular Location |
Isoform PRMT2L2: Cytoplasm {ECO:0000269|PubMed:21820040}. Nucleus {ECO:0000269|PubMed:21820040}. Note=Predominantly cytoplasmic.
|
| Tissue Specificity |
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. {ECO:0000269|PubMed:17587566}.
|