PRMT2

Gene Symbol PRMT2
Entrez Gene 3275
Alt Symbol HRMT1L1
Species Human
Gene Type protein-coding
Description protein arginine methyltransferase 2
Other Description HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1|HMT1 hnRNP methyltransferase-like 1|PRMT2 alpha|PRMT2 beta|PRMT2 gamma|histone-arginine N-methyltransferase PRMT2|protein arginine N-methyltransferase 2
Swissprots Q6FHF0 B7U631 P78350 Q9BW15 P55345 Q99781 Q5U7D4 Q9UMC2 B7U632 Q498Y5 B7U630
Accessions CBX51391 EAX09258 EAX09259 EAX09260 EAX09261 EAX09262 EAX09263 EAX09264 EAX09265 P55345 AF059319 AAG43116 AI801643 AK055950 AK095641 AK123352 AK123650 BAG53931 AK124494 AK223157 BAD96877 AK312573 AL109794 CAB52454 AL833586 AY786414 AAV48568 BC000727 AAH00727 BC038765 AAH38765 BC100026 AAI00027 BF683143 BM976817 BQ267811 BQ421001 BY799824 CA427786 CB045875 CB529922 CN293838 CR541804 CAG46603 DA169949 DA517312 DA708321 DB160043 DQ892126 ABM83052 DQ895319 ABM86245 FJ436410 ACJ66866 FJ436411 ACJ66867 FJ436412 ACJ66868 U79286 AAB50221 U80213 AAB48437 X99209 CAA67599 XM_005261111 XP_005261168 XM_006723998 XP_006724061 XM_006723999 XP_006724062 XM_006724000 XP_006724063 NM_001242864 NP_001229793 NM_001242865 NP_001229794 NM_001242866 NP_001229795 NM_001286676 NP_001273605 NM_001286677 NP_001273606 NM_001286678 NP_001273607 NM_001535 NP_001526 NM_206962 NP_996845
Function Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. {ECO:0000269|PubMed:12039952, ECO:0000269|PubMed:16648481, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19405910}.
Subcellular Location Isoform PRMT2L2: Cytoplasm {ECO:0000269|PubMed:21820040}. Nucleus {ECO:0000269|PubMed:21820040}. Note=Predominantly cytoplasmic.
Tissue Specificity Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. {ECO:0000269|PubMed:17587566}.

PRMT2 (C-3) - sc-514133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT2 (C-3): sc-514133. Western blot analysis of PRMT2 expression in non-transfected: sc-117752 (A) and human PRMT2 transfected: sc-172533 (B) 293T whole cell lysates.

PRMT2 (E-12) - sc-390089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT2 (E-12): sc-390089. Western blot analysis of PRMT2 expression in non-transfected: sc-117752 (A) and human PRMT2 transfected: sc-172533 (B) 293T whole cell lysates.

PRMT2 (B-11) - sc-393254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT2 (B-11): sc-393254. Western blot analysis of PRMT2 expression in non-transfected 293T: sc-117752 (A), human PRMT2 transfected 293T: sc-172533 (B), HeLa (C) and Jurkat (D) whole cell lysates and human kidney tissue extract (E).

PRMT2 (K-17) - sc-55001 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRMT2 (K-17): sc-55001. Western blot analysis of PRMT2 expression in non-transfected: sc-117752 (A) and human PRMT2 transfected: sc-172533 (B) 293T whole cell lysates.

PRMT2 (N-19) - sc-55002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PRMT2 (S-20) - sc-55003 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRMT2 (S-20): sc-55003. Western blot analysis of PRMT2 If expression in HeLa nuclear extract.

PRMT2 (H-95) - sc-135010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRMT2 (H-95): sc-135010. Western blot analysis of PRMT2 expression in non-transfected: sc-117752 (A) and human PRMT2 transfected: sc-172533 (B) 293T whole cell lysates.

PRMT2 (Y-20) - sc-55004 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PRMT2 (2439C4a) - sc-81361 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PRMT2 (2439C4a): sc-81361. Western blot analysis of human recombinant PRMT2 fusion protein.

Anti-PRMT2 antibody - ab154154 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PRMT2 antibody (ab154154) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-PRMT2 antibody - ab156801 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-PRMT2 antibody (ab156801) at 2 µg/ml + HeLa cell lysate at 35 µgdeveloped using the ECL technique

Anti-PRMT2 antibody - ab3667 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PRMT2 antibody (ab3667) + HL60 whole cell lysateSecondaryHRP-conjugated anti-rabbit IgG

Anti-PRMT2 antibody [5D10] - ab119193 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D10
All lanes : Anti-PRMT2 antibody [5D10] (ab119193) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY PRMT2 Lysates/proteins at 5 µg per lane.

Anti-PRMT2 antibody [PRMT2-340] - ab50281 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone PRMT2-340

Anti-PRMT2 antibody - ChIP Grade - ab3763 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT2 Antibody - LS-C155214 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE PRMT2 antibody diluted at 1:3000

Anti-PRMT2 Antibody (clone 5D10) - LS-C173321 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRMT2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRMT2.

Anti-PRMT2 Antibody (clone 2439C4a) - LS-C184563 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2439C4a

Anti-PRMT2 Antibody (aa344-375) - LS-C96507 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of PRMT2 (arrow) using rabbit polyclonal PRMT2 Antibody (L359). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PRMT2 gene.

Anti-PRMT2 Antibody (N-Terminus, AP) - LS-C281184 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT2 Antibody (N-Terminus, APC) - LS-C281185 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT2 Antibody (N-Terminus, Biotin) - LS-C281186 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT2 Antibody (N-Terminus, FITC) - LS-C281187 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT2 Antibody (N-Terminus, Azide-free, HRP) - LS-C281188 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT2 Antibody (N-Terminus, PE) - LS-C281189 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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